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作 者:周珍红 邹潇白[2] 张王君 贺健梅[2] 郑军[2] 陈曦[2] ZHOU Zhen-hong;ZOU Xiao-bai;ZHANG Wang-jun;HE Jian-mei;ZHENG Jun;CHEN Xi(School of Public Health,University of South China,Hengyang,Hunan 421001,China;Hunan Provincial Center for Disease Control and Prevention,Changsha,Hunan 410005,China)
机构地区:[1]南华大学公共卫生学院,湖南衡阳421001 [2]湖南省疾病预防控制中心,湖南长沙410005
出 处:《实用预防医学》2023年第5期524-527,共4页Practical Preventive Medicine
基 金:国家科技重大专项(2017ZX10201101-002-009)。
摘 要:目的 了解2021年湖南省HIV-1传播性耐药流行特征,为优化艾滋病抗病毒治疗提供数据支持。方法 招募湖南省2021年新报告的HIV-1感染者,从全血样本中提取HIV-1 DNA,采用PCR反应及Sanger测序获取pol基因区段序列,序列上传至斯坦福HIV耐药数据库进行耐药分析。结果 共纳入348例未治疗患者,有334例成功测序,14例(4.2%,14/334)出现存在低度以上耐药的突变,其中13例(3.9%,13/334)有非核苷类反转录酶抑制剂(nonnucleoside reverse transcriptase inhibitors, NNRTIs)耐药突变位点,以K103N为主(3.3%,11/334);2例(0.6%,2/334)有核苷类反转录酶抑制剂(nucleoside reverse transcriptase inhibitors, NRTIs)耐药突变位点,包括M184I(0.6%,2/334)和K65R(0.3%,1/334)。结论 2021年湖南省未治疗人群的HIV-1传播性耐药处于低流行水平,建议在实施抗病毒治疗前开展HIV-1传播性耐药监测。Objective To understand the epidemic characteristics of HIV-1 transmitted drug resistance in Hunan Province in 2021,and to provide data support for optimizing HIV antiretroviral therapy.Methods Newly reported people living with HIV-1 in Hunan Province in 2021 were recruited.HIV-1 DNA was extracted from whole blood samples,the sequence of pol gene segment was sequenced by polymerase chain reaction and Sanger sequencing,and the sequence was uploaded to Stanford HIV drug resistance database for drug resistance analysis.Results A total of 348 antiretroviral-naive patients were included,of which 334 subjects were successfully sequenced.14(4.2%,14/334)subjects were found to have low-,medium-and high-drug resistance,of which 13(3.9%,13/334)subjects had nonnucleoside reverse transcriptase inhibitors(NNRTIs)resistance mutation sites,predominantly K103,accounting for 3.3%(11/334).2 subjects(0.6%,2/334)had nucleoside reverse transcriptase inhibitors(NRTIs)resistance mutation sites,including M184I(0.6%,2/334)and K65R(0.3%,1/334).Conclusion HIV-1 transmitted drug resistance in the antiretroviral-naive population in Hunan Province in 2021 was at a low prevalence level.HIV-1 transmitted drug resistance surveillance is recommended prior to the implementation of antiretroviral therapy.
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