聚多卡醇泡沫硬化剂治疗术与腔内激光闭合术对下肢浅静脉曲张的疗效  

Effect of polydocartol foam sclerotherapy and intracavitary laser closure on superficial varicose veins of lower extremity

作　　者：林万里[1] 吴忠寅[1] 丁锐[1] Lin Wanli;Wu Zhongyin;Ding Rui(Department of Vascular Surgery,Hefei First People's Hospital(the Third Affiliated Hospital of Anhui Medical University),Hefe 230001,Anhui,China)

机构地区：[1]合肥市第一人民医院(安徽医科大学第三附属医院)血管外科,安徽合肥230001

出　　处：《血管与腔内血管外科杂志》2023年第4期416-420,共5页Journal of Vascular and Endovascular Surgery

基　　金：安徽省中央引导地方科技发展项目(202007d07050004)。

摘　　要：目的 探讨聚多卡醇泡沫硬化剂治疗术与腔内激光闭合术对下肢浅静脉曲张的疗效。方法 选取2018年1月至2022年1月于合肥市第一人民医院(安徽医科大学第三附属医院)就诊的94例下肢浅静脉曲张患者为研究对象,采用随机数字表法将其分为A组(n=47,行3%聚多卡醇泡沫硬化剂治疗术)、B组(n=47,行腔内激光闭合术)。比较两组患者临床疗效、手术情况、应激相关指标、血管内皮功能相关指标及并发症发生情况。结果 两组患者总有效率比较,差异无统计学意义(P﹥0.05)。A组患者手术时间、住院时间均明显短于B组患者,穿刺点数明显少于B组患者,差异均有统计学意义(P﹤0.05)。术后24 h,两组患者皮质醇(Cor)、去甲肾上腺素(NE)及血管紧张素(Ang-Ⅱ)水平均高于本组术前,且B组患者Cor、NE、Ang-Ⅱ水平均高于A组患者,差异均有统计学意义(P﹤0.05)。术后24 h,两组患者外周血循环内皮细胞计数(CEC)、内皮素-1(ET-1)及一氧化氮(NO)水平均低于本组术前,但B组患者CEC、ET-1、NO水平均高于A组患者,差异均有统计学意义(P﹤0.05)。两组患者并发症发生率比较,差异无统计学意义(P﹥0.05)。结论 3%聚多卡醇泡沫硬化剂治疗术与腔内激光闭合术治疗下肢浅静脉疗效相当,但聚多卡醇泡沫硬化术在手术时间、住院时间、穿刺点数、应激相关指标及血管内皮功能相关指标改善方面均优于腔内激光闭合术。Objective To explore the efficacy of lauryl alcohol foam sclerotherapy and intracavitary laser closure in superficial varicose veins of lower extremity.Method A total of 94 patients with superficial varicose veins of lower extremity admitted to Hefei First People's Hospital(the Third Affiliated Hospital of Anhui Medical University)from January 2020 to January 2022 were collected,and the patients were divided into group A(n=47,treated with lauryl alcohol foam sclerosing)and group B(n=47,treated with intracavitary laser closure)according to random number table.The clinical efficacy,surgery,stress-related indicators,vascular endothelial function-related indicators and complications were compared between the two groups.Result There was no significant difference for the total effective rate in two groups(P﹥0.05).The operation time,hospital stay and number of puncture points in group A were lower than those in group B,the differences were statistically significant(P﹤0.05).The levels of cortisol(Cor),norepinephrine(NE)and angiotensin(Ang-II)in both groups 24 h after surgery increased,the levels of those in group B were higher than those in group A,the differences were statistically significant(P﹤0.05).The levels of peripheral blood endothelial cell count(CEC),endothelin-1(ET-1)and nitric oxide(NO)in both groups decreased 24 h after surgery,but the levels of those in group B were higher than those in group A,the differences were statistically significant(P﹤0.05).There was no significant difference for complications between the two groups(P﹥0.05).Conclusion The efficacy of lauryl foam sclerotherapy and intracavitary laser closure in the treatment of superficial varicose veins of lower extremity is comparable,however,lauryl alcohol foam sclerotherapy is superior to endoluminal laser closure in terms of operation time,hospital stay,number of puncture points,stress-related indicators and vascular endothelial function-related indicators.

关 键 词：聚多卡醇泡沫硬化剂治疗术 腔内激光闭合术 下肢浅静脉曲张 疗效 

分 类 号：R543[医药卫生—心血管疾病]