白鲜皮化学成分、药理作用和毒性研究进展及质量标志物预测分析  

Research progress in chemical composition,pharmacological effects,toxicology of Dictamni cortex and predictive analysis of its quality markers

作　　者：刘新月 陈乐乐 孙鹏[1] 展照双[1] 王加锋[1] LIU Xin-yue;CHEN Le-le;SUN Peng;ZHAN Zhao-shuang;WANG Jia-feng(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国新药杂志》2023年第8期799-805,共7页Chinese Journal of New Drugs

基　　金：齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术);齐鲁医派中医学术流派传承项目(齐鲁温病流派通腑辨治热病中医药特色技术);山东省研究生教育质量提升计划(SDYKC21047);山东省中医药科技发展计划项目(2019-0042);山东省中医药科技发展计划项目(2015-513)。

摘　　要：白鲜皮为芸香科白鲜属植物白鲜(Dictamnus dasycarpus Turcz.)的干燥根皮,已发现含有生物碱类、柠檬苦素类、苯丙素类、黄酮类等成分。本文在对白鲜皮化学成分、药理作用和毒性进行综述的基础上,围绕中药质量标志物(Q-marker)概念,从植物亲缘学和成分可测性、传统药效、传统药性、产地和采收时期及不同紫外辐射强度下成分含量等方面对白鲜皮Q-marker成分进行预测分析,发现γ-崖椒碱、柠檬苦素、白鲜碱、黄柏酮和梣酮可作为白鲜皮Q-marker指标,以期为白鲜皮科学质量标准的建立提供参考。Dictamni cortex is the dried root bark of the Dictamnus L.in the Rutaceae family.It contains alkaloids,limonoids,phenylpropanoids,flavonoids,et al.Based on summarization of its chemical components,pharmacological effects and toxicity,and according to the concept of traditional Chinese medicine quality marker(Q-marker),the Q-markers of Dictamni cortex were predicted from the aspects of genetic relationship and measurability of components,traditional efficacy,traditional property,different producing areas and collecting periods,and component contents under different ultraviolet radiation intensities.-fagarine,limonin,dictamnine,obacunone and fraxinellone can be used as Q-markers of Dictamni cortex,which provide a scientific reference for the establishment of quality standards.

关 键 词：白鲜皮 化学成分 药理作用 质量标志物 预测分析 

分 类 号：R917[医药卫生—药物分析学]