“一锅法”合成(E)-2-苯乙烯基喹啉-3,4-二酸二乙酯类衍生物  

One-pot Synthesis of (E)-Diethyl 2-styrylquinoline-3,4-dicarboxylate Derivatives

作　　者：赵頔 刘延鹰 王洋[3] 李阳[1] Zhao Di;Liu Yanying;Wang Yang;Li Yang(College of Chemistry and Materials Engineering,Bohai University,Jinzhou,121000;Research Institute of Jinzhou Petrochemical Company,Jinzhou,121000;Center of Experiment and Equipment Management,Bohai University,Jinzhou,121000)

机构地区：[1]渤海大学化学与材料工程学院,锦州121000 [2]锦州石化分公司研究院,锦州121000 [3]渤海大学实验与设备管理中心,锦州121000

出　　处：《化学通报》2023年第5期589-597,513,共10页Chemistry

基　　金：国家自然科学基金项目(21878023,U1608222);辽宁省特聘教授项目;辽宁省教育厅“青年育苗”项目(LQ2019006);辽宁省科技厅博士启动项目(2019-BS-004)资助。

摘　　要：本文设计以2-溴甲基喹啉-3,4-二甲酸二乙酯为起始化合物,经一锅连续的Arbuzov反应/Horner-Wadsworth-Emmons(HWE)反应过程,简便而有效地合成了一系列结构新颖的(E)-2-苯乙烯基喹啉-3,4-二羧酸二乙酯类衍生物(3a~3i),其结构均已通过波谱数据和元素分析得以证实。In the present work, a simple and flexible synthesis of a series of novel (E)-diethyl 2-styrylquinoline-3,4-dicarboxylates 3a-i has been achieved for the first time in good yields, involving one-pot sequential Arbuzov/Horner–Wadsworth–Emmons (HWE) reaction sequence using diethyl 2-(bromomethyl) quinoline-3,4-dicarboxylate as substrate. The molecular structures of these newlysynthesized products were confirmed by spectral data and elemental analyses.

关 键 词：溴甲基 苯乙烯基喹啉 一锅法 Arbuzov反应 HWE反应 

分 类 号：O626.323[理学—有机化学] TQ460.1[理学—化学]