脂肪间充质干细胞治疗糖尿病及其慢性并发症的研究进展  

Advances of adipose-derived mesenchymal stem cells in the treatment of diabetes mellitus and its chronic complications

作　　者：郭庆 李冠琳 刘慧[1] 魏炜[1] 于洋[1] 张纯[1] Guo Qing;Li Guanlin;Liu Hui;Wei Wei;Yu Yang;Zhang Chun(Clinical Stem Cell Research Center,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院临床干细胞研究中心,100191

出　　处：《中华细胞与干细胞杂志（电子版）》2023年第1期58-62,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金项目(82101780);北京大学第三医院临床重点项目(BYSYZD2021031)。

摘　　要：糖尿病是常见的慢性病之一,持续的高血糖状态可以引起大血管系统和微血管系统的多种慢性并发症,是造成糖尿病患者死亡的主要原因。脂肪间充质干细胞(ADSCs)具有取材方便、分离简单和易于培养等特点,在治疗糖尿病及其慢性并发症方面表现出广阔应用潜力,现将近年来ADSCs在糖尿病及其慢性并发症治疗中取得的研究进展进行综述。Diabetes mellitus is one of the most common and severe chronic diseases worldwide.Continuous hyperglycemia leads to various of chronic complications in the macrovascular and microvascular systems,which is the main cause of death in patients with diabetes.Adipose-derived mesenchymal stem cells(ADSCs),which are easy to obtain,simple to isolate and easy to culture,have shown great potential in treating diabetes mellitus and its chronic complications.This paper reviews the research progress of ADSCs in treating diabetes mellitus and its chronic complications in recent years.

关 键 词：脂肪间充质干细胞 糖尿病 胰岛Β细胞 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]