基于立方液晶载体的5-氨基酮戊酸纳米经皮给药制剂研究  

Study on nanometer percutaneous delivery preparation of 5-aminophenolvalic acid based on cubic liquid crystal

作　　者：曾令军 胡晓木 刘志宏 郑长青 姚玲艳 缪陈芳 周欣 ZENG Ling-jun;HU Xiao-mu;LIU Zhi-hong;ZHENG Chang-qing;YAO Ling-yan;MIAO Chen-fang;ZHOU Xin(Department of Pharmacy,900 hospital of the joint logistics team,Fujian Fuzhou 350025,China)

机构地区：[1]联勤保障部队第九〇〇医院药剂科,福建福州350025

出　　处：《中国医院药学杂志》2023年第8期877-881,共5页Chinese Journal of Hospital Pharmacy

基　　金：福建省自然科学基金项目(编号:2022J011092,2019J101523);联勤保障部队第九〇〇医院院内课题(编号:2021MS06)。

摘　　要：目的:评价立方液晶载体对5-氨基酮戊酸皮肤渗透性、光动力疗效、稳定性等的影响。方法:以累积渗透量和皮肤滞留量为评价指标,比较5-氨基酮戊酸水溶液(ALA-W)、5-氨基酮戊酸立方液晶纳米凝胶(ALA-CS)的皮肤渗透性差异;以细胞存活率为评价指标,比较ALA-W、ALA-CS的光动力疗效差异;比较ALA-W、ALA-CS的高温稳定性和强光照稳定性。结果:10%ALA-CS的4 h累积渗透量(Q4)和皮肤滞留量显著高于10%ALA-W(P<0.05),但低于20%ALA-W(P<0.05);ALA-CS的光毒性在各个考察浓度均大于ALA-W;ALA-W高温、强光照下不稳定,ALA-CS在高温、强光照下均呈现较好的稳定性。结论:立方液晶载体能有效提高5-氨基酮戊酸的皮肤渗透性、光动力疗效及稳定性,是一种优良的经皮给药制剂载体。OBJECTIVE To evaluate the effect of cubic liquid crystal on skin permeability,photodynamic efficacy and stability of 5-aminolevulinic acid.METHODS The skin permeability of 5-aminolevulinic acid aqueous solution(ALA-W)and 5-aminolevulinic acid cubic liquid crystal nanogels(ALA-CS)were compared by using cumulative permeability andskin retentionas the evaluation indexes.The photodynamic efficacy of ALA-W and ALA-CS was compared using cell viability as the evaluation index.The stability of ALA-W and ALA-CS at high temperature and strong light were studied.RESULTS The 4-hour cumulative permeability(Q4)andskin retentionof 10%ALA-CS were significantly higher than that of 10%ALA-W(P<0.05),while lower than that of 20%ALA-W(P<0.05).ALA-W is unstable under high temperature and strong light,while ALA-CS is stable.CONCLUSION The cubic liquid crystal can effectively improve the skin permeability,photodynamic efficacy and stability of 5-aminophenolvalic acid,which is an excellent carrier for transdermal drug delivery.

关 键 词：5-氨基酮戊酸 立方液晶 皮肤渗透性 光动力疗效 稳定性 

分 类 号：R944[医药卫生—药剂学]