异戊烯基黄酮的化学结构、药理活性及生物合成研究进展  

Research Progress on Chemical Structure,Pharmacological Effect and Biosynthesis of Prenylated Flavonoids

作　　者：唐媛媛 牛腾飞 叶菊 王如锋 Tang Yuanyuan;Niu Tengfei;Ye Ju;Wang Rufeng(School of Pharmacy,Qinghai Nationalities University,Xining,810007;Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai,201203;The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,201203)

机构地区：[1]青海民族大学药学院,西宁810007 [2]上海中医药大学中药研究所,上海201203 [3]上海中医药大学,中药新资源与品质评价国家中医药管理局重点研究室,上海201203

出　　处：《分子植物育种》2023年第10期3319-3329,共11页Molecular Plant Breeding

基　　金：青海省科技厅基础研究项目(2021-ZJ-707);中国博士后科学基金会特别资助(2021T140466);中国博士后科学基金会面上项目(2020M681371)共同资助。

摘　　要：异戊烯基黄酮(Prenylated flavonoid)有多种生理活性,可作为医疗药物、保健品、植物抗生素、食品添加剂,广泛应用于医疗保健、农业、食品等领域。本研究基于异戊烯基黄酮的化学分类和生物活性,黄酮异戊烯基转移酶(Flavonoid prenyltransferase)的来源和功能特点,异戊烯基黄酮的生物合成方法和优化方面进行阐述,并对异戊烯基黄酮生物合成的应用前景进行展望,为异戊烯基黄酮的相关研究提供参考。Prenylated flavonoids have a variety of physiological activities,which can be used as medical drugs,health products,plant antibiotics,and food additives in medical care,agriculture,food and other fields.This review mainly focuses on the biosynthesis of prenylated flavonoids and their classifications and biological activities,as well as the sources and catalytic characteristics of flavonoid prenyltransferases.It also prospects the application of prenylated flavonoids biosynthesis to provide reference for associated research of prenylated flavonoids.

关 键 词：异戊烯基黄酮 黄酮异戊烯基转移酶 生物合成 异戊烯基供体 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]