中国9个长寿地区≥65岁老年人超敏C反应蛋白水平与虚弱及其组分的关联研究  

Association of hs-CRP with frailty and its components among the elderly over 65 years old in 9 longevity areas of China

作　　者：刘俊鑫 魏源 周锦辉 王君[1] 宋皓璨 李昕蔚 向长贞 徐毅博 丁聪 钟振宇 章正 罗宇菲 赵峰[1] 陈晨[1] 皮静波[2] Liu Junxin;Wei Yuan;Zhou Jinhui;Wang Jun;Song Haocan;Li Xinwei;Xiang Changzhen;Xu Yibo;Ding Cong;Zhong Zhenyu;Zhang Zheng;Luo Yufei;Zhao Feng;Chen Chen;Pi Jingbo(China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;School of Public Health,China Medical University,Shenyang 110001,China)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室、中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]中国医科大学公共卫生学院,沈阳110001

出　　处：《中华预防医学杂志》2023年第5期626-633,共8页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(82025030,82003550,81872707,81941023)。

摘　　要：目的研究中国9个长寿地区≥65岁老年人超敏C反应蛋白水平(hs-CRP)与虚弱及其组分的关联。方法利用“老年健康生物标志物队列研究”项目中2017—2018年的横断面数据,将≥65岁老年人纳入研究。通过问卷调查和体格检查,收集调查对象的人口学特征、行为方式、膳食情况、日常活动能力、认知功能、自我健康状况、现患疾病情况等信息。采用多因素logistic回归模型和限制性立方样条分析老年人hs-CRP与虚弱及其组分的关联。结果本研究共纳入2453名研究对象,年龄为(84.8±19.8)岁,hs-CRP水平的中位数为1.13 mg/L;虚弱的患病率为24.4%(598/2453)。调整混杂因素后,与低水平组(hs-CRP<1.0 mg/L)相比,高水平组(hs-CRP>3.0 mg/L)OR(95%CI)值为1.79(1.35~2.36)。调整混杂因素后,对hs-CRP水平与虚弱各组分的多因素logistic回归模型分析结果显示,与低水平组相比,日常生活自理能力(ADL)受损、器具性日常生活自理能力(IADL)受损、功能限制、共病在高水平组OR(95%CI)值分别为1.68(1.25~2.27)、1.88(1.42~2.50)、1.68(1.31~2.14)和1.39(1.12~1.72)。结论中国9个长寿地区≥65岁老年人hs-CRP水平与虚弱风险存在正向关联,较高的hs-CRP水平可能通过增加ADL受损、IADL受损、功能限制和共病,从而增加老年人的虚弱风险。Objective To investigate the association of the levels of high sensitivity C-reactive protein(hs-CRP)with frailty and its components among the elderly over 65 years old in 9 longevity areas of China.Methods Cross-sectional data from the Health Ageing and Biomarkers Cohort Study(HABCS,2017-2018)were used and the elderly over 65 years old were included in this study.Through questionnaire interview and physical examination,the information including demographic characteristics,behavior,diet,daily activity,cognitive function,and health status was collected.The association between hs-CRP and frailty and its components in the participants was analyzed by multivariate logistic regression model and restrictive cubic spline.Results A total of 2453 participants were finally included,the age was(84.8±19.8)years old.The median hs-CRP level was 1.13 mg/L and the prevalence of frailty was 24.4%.Compared with the low-level group(hs-CRP<1.0 mg/L),the OR(95%CI)value of the high-level group(hs-CRP>3.0 mg/L)was 1.79(1.35-2.36)mg/L.As for the components,the hs-CRP level was also positively associated with ADL disability,IADL disability,functional limitation and multimorbidity.After adjusting for confounding factors,compared with the low-level group,the OR(95%CI)values of the high-level group for the four components were 1.68(1.25-2.27),1.88(1.42-2.50),1.68(1.31-2.14)and 1.39(1.12-1.72),respectively.Conclusion There is a positive association between the levels of hs-CRP and the risk of frailty among the elderly over 65 years old in 9 longevity areas of China.The higher hs-CRP level may increase the risk of frailty by elevating the risk of four physical functional disabilities,namely ADL disability,IADL disability,functional limitation and multimorbidity.

关 键 词：虚弱 超敏C反应蛋白 炎症 老年人 横断面研究 

分 类 号：R195[医药卫生—卫生统计学]