新型冠状病毒疫苗接种人群中一起新型冠状病毒感染聚集性疫情流行病学特征及血清抗体检测分析  

Epidemiological characteristics and serum antibody detection of a COVID-19 aggregated outbreak in vaccinated population

作　　者：任振勇[1] 龚海英 辛丹[3] 张莉[1] 李爽[1] 张昕 陈萌[4] 庞星火[1] Ren Zhenyong;Gong Haiying;Xin Dan;Zhang Li;Li Shuang;Zhang Xin;Chen Meng;Pang Xinghuo(Beijing Center for Disease Control and Prevention,Institute of Infectious and Endemic Disease Control,Beijing 100013,China;Department of Planned Immunization,Fangshan District Center for Disease Control and Prevention,Beijing 102401,China;Department of Infectious Diseases and Endemic Diseases,Fangshan District Center for Disease Control and Prevention,Beijing 102401,China;Beijing Center for Disease Control and Prevention,Institute of Immunization,Beijing 100013,China)

机构地区：[1]北京市疾病预防控制中心传染病地方病控制所,北京100013 [2]北京市房山区疾病预防控制中心计划免疫科,北京102401 [3]北京市房山区疾病预防控制中心传染病地方病科,北京102401 [4]北京市疾病预防控制中心免疫预防所,北京100013

出　　处：《中华预防医学杂志》2023年第5期728-731,共4页Chinese Journal of Preventive Medicine

基　　金：北京市科委医药创新品种及平台培育项目(Z211100002521019)。

摘　　要：对北京市2022年一起新型冠状病毒疫苗接种人群新型冠状病毒感染聚集性疫情进行流行病学调查,并采集21例感染者和61例密切接触者血清标本(其中20例隔离观察期核酸转阳)。抗体检测结果显示:2例感染者IgM抗体阳性,密接转阳者、密接未转阳者和感染者的IgG抗体阳性率分别为36.84%(7/19)、63.41%(26/41)和71.43%(15/21)。98.78%的对象曾接种新型冠状病毒灭活疫苗,3剂疫苗接种者IgG抗体阳性率为86.00%(43/50),高于1~2剂者[16.12%(5/31)];3剂接种者抗体水平[M(Q_(1),Q_(3))为4.255(2.303,7.0375)]高于1~2剂接种者[M(Q_(1),Q_(3))为0.000(0.000,0.000)](均P<0.001)。末次接种时间<3个月者抗体水平M(Q_(1),Q_(3))为7.335(1.909,7.858),高于接种时间≥3个月者[M(Q_(1),Q_(3))为2.125(0.000,4.418)](P=0.007)。3剂次密接转阳者IgG抗体阳性率和抗体水平M(Q_(1),Q_(3))分别为77.78%(7/9)和4.207(2.216,7.099),均高于1~2剂次者[分别为0和0.000(0.000,0.000)](均P<0.05)。An epidemiological investigation was conducted on a cluster epidemic of COVID-19 in the vaccinated population in Beijing in 2022,and serum samples were collected from 21 infected cases and 61 close contacts(including 20 cases with positive nucleic acid in the isolation observation period).The results of antibody detection showed that the IgM antibody of two infected persons was positive,and the IgG antibody positive rates of patients who were converted,not converted to positive and infected persons were 36.84%(7/19),63.41%(26/41)and 71.43%(15/21),respectively.About 98.78%of patients had been vaccinated with the SARS-CoV-2 inactivated vaccine.The positive rate of IgG antibody in patients immunized with three doses of vaccine was 86.00%(43/50),which was higher than that in patients with one or two doses[16.12%(5/31)].The antibody level of M(Q_(1),Q_(3))in patients immunized with three doses was 4.255(2.303,7.0375),which was higher than that in patients with one or two doses[0.500(0.500,0.500)](all P values<0.001).The antibody level of patients who were vaccinated less than three months[7.335(1.909,7.858)]was higher than that of patients vaccinated more than three months after the last vaccination[2.125(0.500,4.418)](P=0.007).The positive rate and level of IgG antibody in patients who were converted to positive after three doses were 77.78%(7/9)and 4.207(2.216,7.099),respectively,which were higher than those in patients who were converted after one or two doses[0 and 0.500(0.500,0.500)](all P values<0.05).

关 键 词：血清流行病学研究 免疫接种 加强 新型冠状病毒 奥密克戎变异株 

分 类 号：R186[医药卫生—流行病学]