乙型肝炎疫苗初次免疫低/无应答婴儿再免后的免疫记忆持久性随访观察  

Persistence follow-up of immune memory to hepatitis B vaccine among infants with non- and low-response to primary vaccination after revaccination with three doses

作　　者：吕静静[1,2] 颜丙玉 冯艺[1] 孟鑫[1] 赵雪 窦璇 梁晓峰 王富珍[4] 徐爱强[1] 张丽[1,2] Lyu Jingjing;Yan Bingyu;Feng Yi;Meng Xin;Zhao Xue;Dou Xuan;Liang Xiaofeng;Wang Fuzhen;Xu Aiqiang;Zhang Li(Expanded Program Immunizatin Division,Shandong Provincial Center for Disease Control and Prevention,Jinan 250014,China;School of Pubic Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;School of Medicine,Jinan University,Guangzhou 510632,China;Center for National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]山东省疾病预防控制中心免疫预防管理所、山东省传染病预防控制重点实验室,济南250014 [2]山东大学齐鲁医学院公共卫生学院,济南250012 [3]暨南大学基础医学与公共卫生学院,广州510632 [4]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中华预防医学杂志》2023年第5期732-735,共4页Chinese Journal of Preventive Medicine

基　　金：国家科学技术艾滋病和病毒性肝炎等重大传染病防治重大专项(2012ZX10002001,2013ZX10004902,2018ZX10721202);山东省泰山学者工程(ts201511105)。

摘　　要：本研究对乙型肝炎疫苗(HepB)初次免疫低/无应答婴儿再次免疫后的免疫记忆进行了随访观察,最终将随访时抗-HBs<10 mIU/ml(抗-HBs阴性)且未进行自行加强免疫的120名儿童纳入研究,其中有86名儿童完成采血和抗-HBs检测。接种激发剂次前,86名儿童抗-HBs全部阴性,抗-HBs的GMC均<10 mIU/ml;激发剂次接种后,抗-HBs阳转率为100%,抗-HBs的GMC为886.11(95%CI:678.15~1157.84)mIU/ml。与接种激发剂次前抗-HBs<4 mIU/ml者相比,抗-HBs>7 mIU/ml者接种激发剂次后的抗-HBs水平较高,β(95%CI)值为0.82(0.18~1.46)(P=0.012);与初次免疫后抗-HBs<1000 mIU/ml者相比,初次免疫后抗-HBs≥1000 mIU/ml者接种激发剂次后的抗-HBs水平较高,β(95%CI)值为0.78(0.18~1.38)(P=0.012)。结果提示,HepB初次免疫低/无应答婴儿再次免疫9年后仍存在较强免疫记忆。This study followed up the immune memory after 3-dose revaccination among infants with non-and low-response following primary hepatitis B(HepB)vaccination.About 120 children without self-booster doses were finally included who had anti-HBs<10 mIU/ml(anti-HBs negative)at the time of follow-up,of whom 86 children completed blood sampling and anti-HBs testing.Before the challenge dose,all 86 children were negative for anti-HBs,and the GMC of anti-HBs was<10 mIU/ml.The seropositive conversion rate of anti-HBs was 100%and the GMC of anti-HBs was 886.11(95%CI:678.15-1157.84)mIU/ml after the challenge dose.Compared with those with GMC<7 mIU/ml before the challenge dose,infants with GMC>7 mIU/ml had a higher anti-HBs level after the challenge dose.Theβvalue(95%CI)was 0.82(0.18-1.46)(P=0.012).Compared with those with GMC<1000 mIU/ml at primary vaccination,infants with GMC≥1000 mIU/ml had a higher anti-HBs level after the challenge dose.Theβvalue(95%CI)was 0.78(0.18-1.38)(P=0.012).The results showed a stronger immune memory was found at 9 years after revaccination among infants with non-and low-response to HepB.

关 键 词：肝炎疫苗 乙型 婴儿 低/无应答者 免疫记忆 

分 类 号：R725.1[医药卫生—儿科]