子宫内膜类器官研究进展  

Research advances in endometrial organoids

作　　者：李文鑫 周争立[2] Li Wenxin;Zhou Zhengli(Institute of Primate Translational Medicine,Kunming University of Science and Technology State Key Laboratory of Primate Biomedical Research,Kunming 650500,China;Department of Gynecology,the First People's Hospital of Yunnan Province(Affiliated Hospital of Kunming University of Science and Technology),Kunming 650031,China)

机构地区：[1]昆明理工大学灵长类转化医学研究院、省部共建非人灵长类生物医学国家重点实验室,昆明650500 [2]云南省第一人民医院(昆明理工大学附属医院)妇科,昆明650031

出　　处：《中华生殖与避孕杂志》2023年第4期422-427,共6页Chinese Journal of Reproduction and Contraception

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项面上项目(2019FE001(-296));云南省第一人民医院重点专科开放项目(2022FKZDZK-08)。

摘　　要：子宫内膜类器官(endometrial organoids,EOs)是子宫内膜细胞自组织的三维聚集物,代表子宫内膜的结构和功能。根据所包含的细胞类型的数量,EOs可分为两类:单种细胞EOs和多种细胞EOs。EOs将加速我们对子宫内膜发育和疾病的分子和细胞机制的理解,将成为从疾病建模到个性化医疗等生物医学应用的有前途的工具。本文对EOs的表型(典型的表面标记和结构)、遗传特征、培养基、对激素的反应、模拟的疾病模型、挑战和未来展望逐一综述。Endometrial organoids(EOs)are three-dimensional aggregates of endometrial cells,which represent the structure and function of endometrium.According to the number of cell types contained,EOs can be divided into two categories,single-cell EOs and multicellular EOs.EOs will accelerate our understanding of the molecular and cellular mechanisms of endometrial development and diseases,and will become a promising tool for biomedical applications from disease modeling to personalized medicine.This review described the phenotype(typical surface markers and structure),genetic characteristics,culture medium,response to hormones,simulated disease model,challenges and future prospects of EOS.

关 键 词：类器官 子宫内膜异位症 子宫内膜增生 子宫内膜炎 多囊卵巢综合征 子宫内膜 子宫内膜癌 

分 类 号：R318.1[医药卫生—生物医学工程]