Nanocoating of CsgA protein for enhanced cell adhesion and proliferation  

作　　者：Chao Yang Dan Li Shaohong Zang Yingtang Zhou Lei Zhang Zhangfeng Zhong 

机构地区：[1]National Engineering Research Center for Marine Aquaculture,Institute of Innovation&Application,Zhejiang Ocean University,Zhoushan 316022,China [2]State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [3]Department of Chemical Engineering,Waterloo Institute for Nanotechnology,University of Waterloo,Waterloo,ON N_(2)L3G1,Canada [4]Macao Centre for Research and Development in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China

出　　处：《Chinese Chemical Letters》2023年第4期154-157,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 82104477, U19A2010, and 81891012);special support from China Postdoctoral Science Foundation(Nos. 2019M663456 and 2019TQ0044);Xinglin Scholar Research Promotion Project of Chengdu University of TCM (No.BSH_(2)019008);National Interdisciplinary Innovation Team of Traditional Chinese Medicine (No. ZYYCXTD-D-202209);the Macao Science and Technology Development Fund (No. FDCT 007/2020/ALC);the Shenzhen-Hong Kong-Macao S&T Program (Category C)(No. SGDX2020110309420200);the Research Fund of University of Macao (No. CPG2022-00005-ICMS)。

摘　　要：Immune rejection, poor biocompatibility and cytotoxicity have seriously stalled the widespread application of biometallic materials. To overcome these problems, biometallic materials with fast and sufficient osseointegration, antibacterial properties and long-term stability have attracted the attention of researchers worldwide. Surface modification is currently used as a general strategy to develop material coatings that will overcome these challenging requirements and achieve the successful performance of implants. In this study, we proposed a substrate surface-modification strategy based on biofilm Csg A proteins that promote rapid cell attachment, proliferation, and stabilization of the cytoskeleton. Csg A-based nano-coating is easy to fabricate and has superior performance, which is expected to expand the application of medical implants.

关 键 词：Biocompatibility CsgA Fractal-like morphologies NANOCOATINGS Wound healing 

分 类 号：R318.08[医药卫生—生物医学工程]