Label-free photoelectric sensor for lactic acid determination in human sweat  

作　　者：Hao Gu Guoxin Dai Siyu Liu Yanbing Zhai Qian Xu Hongqiang Wu Wei Xu 

机构地区：[1]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [2]School of Medical Technology,Beijing Institute of Technology,Beijing 100081,China [3]National Institute of Metrology,Beijing 100029,China [4]Biotree Metabolomics Technology Research Center,Shanghai 201800,China

出　　处：《Chinese Chemical Letters》2023年第4期474-478,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 22172040 and 21974031);the Department of Science and Techniques of Guangdong Province (Nos. 2021A1515010180 and 2019B010933001);Guangzhou Municipal Science and Technology Bureau (No. 202102010449);Guangzhou Municipal Science and Technology Bureau (No. GZQC_(2)0-PZ11-FD084) for their financial support。

摘　　要：A label-free lactic acid sensor has been successfully developed by using a Dysprosium single crystal-based photoelectric potential technique via Dy-SCN/FTO electrode. Interestingly, the proposed sensor demonstrated excellent performance for L-lactic acid analysis with a wide linear range of 0.0196~16.31 mmol/L,the detection limit of as low as 3.20 μmol/L as well as an advisable stability. The feasibility of this strategy was also verified by practical application towards human sweat samples. The mechanism studies indicated that lactic acid molecules specifically bind to the surface of semiconductor materials, which alters the charge distribution of the electrode surface and subsequently results in band bending/photoelectric potential changes. The theoretical formula for this photoelectric chemistry(PEC) strategy was then derived according to charge balance theory. We believe that the proposed Dy-SCN/FTO sensor would open a new way for rapid, non-invasive L-lactic acid level evaluation during human physical condition monitoring.

关 键 词：Mass spectrometry INSTRUMENTATION LC-MS IMMUNOSUPPRESSANTS 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] R446.1[自动化与计算机技术—控制科学与工程]