氟硼荧光染料纳米粒子在肿瘤光学成像和光疗中的应用  

Applications of BODIPY Dyes-based Nanoparticles in Tumor Optical Imaging and Phototherapy

作　　者：张远东 张卓 阚君满 ZHANG Yuandong;ZHANG Zhuo;KAN Junman(Dept.of Scientific Research,Jilin Business and Technology College,Changchun 130507)

机构地区：[1]吉林工商学院科研处,吉林长春130507

出　　处：《中国医药工业杂志》2023年第3期330-338,共9页Chinese Journal of Pharmaceuticals

基　　金：吉林省教育厅项目(JJKH20220210KJ)。

摘　　要：氟硼荧光染料(BODIPY dyes)是传统的有机小分子染料,因具有易于改性的结构和可调节的光物理性质,成为人们关注的焦点。经过合理设计的BODIPY能通过多种方式制备成可用于肿瘤光学成像和光学治疗的纳米粒子。首先,该综述介绍了BODIPY纳米粒子的不同构建策略。其后,系统总结了BODIPY纳米粒子在肿瘤荧光成像、光声成像、光动力疗法、光热疗法以及光动力-光热联合治疗中的研究进展。最后,对BODIPY纳米粒子未来的发展方向进行展望。4,4-Difluoro-boradiazaindacene dyes,BODIPY dyes,as traditional small organic molecule dyes,have been of significant interest due to their easy modifiable structures and tunable photophysical properties.The rationally designed BODIPYs could self-assemble into nanoparticles for tumor imaging and phototherapy in many approaches.Initially,different strategies for the construction of BODIPY nanoparticles are introduced in this review.Subsequently,the research progress of BODIPY nanoparticles in tumor fluorescence imaging,photoacoustic imaging,photodynamic therapy,photothermal therapy and combined photodynamic and photothermal therapy are summarized systematically.Finally,the future directions of BODIPY nanoparticles are prospected.

关 键 词：氟硼荧光染料 纳米粒子 生物成像 光动力疗法 光热疗法 

分 类 号：TB34[一般工业技术—材料科学与工程]