妊娠期糖尿病与妊娠期高血压疾病相关性研究进展  

RESEARCH ADVANCES IN THE ASSOCIATION BETWEEN GESTATIONAL DIABETES MELLITUS AND HYPERTENSIVE DI-SORDER COMPLICATING PREGNANCY

作　　者：颜廷媛 陈雅暖 徐金娥[2] 王俊环[2] 崔雪娜[2] YAN Tingyuan;CHEN Yanuan;XU Jin′e;WANG Junhuan;CUI Xuena(Department of Medical Record Management Center,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院病案管理中心,山东青岛266003 [2]青岛大学附属医院产科,山东青岛266003

出　　处：《精准医学杂志》2023年第3期279-282,共4页Journal of Precision Medicine

基　　金：青岛大学附属医院临床医学+X基金(QDFY+X2021008)。

摘　　要：目的 妊娠期糖尿病(gestational diabetes mellitus, GDM)与妊娠期高血压疾病(hyperbensive disorder complicating pregnancy, HDCP)是孕期常见的并发症,其中患有GDM的孕妇并发HDCP的概率约为25%~32%,两者发病高危因素、发病机制、对母婴结局的影响也互相关联。GDM与HDCP共同高危因素有脂代谢紊乱、妊娠感染、吸烟、高龄、心理异常,共同发病机制有胰岛素抵抗、炎症因子及Afamin的释放。GDM及HDCP易与妊娠期甲状腺疾病相伴随,易导致母婴出现不良的结局,如胎膜早破、剖宫产、胎儿窘迫、死胎、新生儿窒息、新生儿畸形等。本文主要探讨分析了GDM与HDCP的关系,以提高临床医生对这两种疾病的认识和临床治疗效果。Gestational diabetes mellitus(GDM)and hypertensive disorder complicating pregnancy(HDCP)are common complications during pregnancy,and the probability of HDCP is as high as 25%-32%in pregnant women with GDM.GDM and HDCP are interrelated from the aspects of high-risk factors,pathogenesis,and impact on maternal and fetal outcome.The common high-risk factors for GDM and HDCP include dyslipidemia,pregnancy infection,smoking,old age,and psychological abnormality,and their common pathogenesis includes insulin resistance,inflammatory factors,and the release of Afamin.GDM and HDCP are often accompanied by thyroid diseases during pregnancy,which may lead to adverse maternal and fetal outcome,such as premature rupture of membranes,cesarean section,fetal distress,stillbirth,neonatal asphyxia,and neonatal malformation.This article mainly discusses and analyzes the association between GDM and HDCP,in order to improve the awareness of these two diseases among clinicians and their treatment outcomes.

关 键 词：糖尿病 妊娠 高血压 妊娠性 妊娠并发症 危险因素 胰岛素抗药性 炎症 细胞因子类 综述 

分 类 号：R714.25[医药卫生—妇产科学]