拉贝洛尔联合硝苯地平对妊娠期高血压患者母婴围生结局改善效果观察  

Observation on improvement of maternal and infant perinatal outcomes in pregnant women with gestational hypertension treated with labetalol combined with nitrendipine

作　　者：傅鑫[1] 郭淼[1] 武海雨 Fu Xin;Guo Miao;Wu Haiyu(Department of ObstetricsⅡ,Nanyang Second General Hospital,Nanyang Henan 473000,China)

机构地区：[1]河南省南阳市第二人民医院产二科,河南南阳473000

出　　处：《保健医学研究与实践》2023年第3期39-42,共4页Health Medicine Research and Practice

摘　　要：目的 观察拉贝洛尔联合硝苯地平对妊娠期高血压(GH)患者母婴围生结局的改善效果,以期为临床决策的制定提供参考。方法 选取河南省南阳市第二人民医院妇产科2020年3月—2022年3月收治的106例GH患者作为研究对象,采用随机数字表法分为观察组和对照组,每组53例。对照组患者给予盐酸拉贝洛尔治疗,观察组患者在对照组基础上联合硝苯地平治疗,连续用药至分娩前。比较2组患者临床疗效、收缩压(SBP)和舒张压(DBP)水平、母婴围生结局和患者不良反应发生情况。结果 对照组患者的治疗总有效率为77.36%,低于观察组患者的94.34%(P<0.05)。治疗前,2组患者SBP和DBP比较,差异均无统计学意义(P>0.05);治疗后,2组患者的SBP和DBP较治疗前均有所下降,且观察组低于对照组,差异均有统计学意义(P<0.05)。同时,观察组患者早产、剖宫产等发生率均明显低于对照组,且差异均有统计学意义(P<0.05);观察组患者胎儿的生长受限、新生儿窒息等发生率均明显低于对照组,且差异均有统计学意义(P<0.05)。对照组患者皮疹、乏力等不良反应的发生率为16.98%,高于观察组的15.09%,但差异无统计学意义(P>0.05)。结论 拉贝洛尔联合硝苯地平治疗能有效控制GH患者的血压水平,提高临床疗效,改善母婴结局,且安全性较高,值得临床推广应用。Objective This paper aims to observe the effect of labetalol combined with nitrendipine on the improvement of maternal and infant perinatal outcomes in patients with gestational hypertension(GH)to provide evidence for clinical decision-making.Methods A total of 106 patients with GH admitted to the Department of ObstetricsⅡof the Nanyang Second General Hospital from March 2020 to March 2022 were selected as the research participants.They were assigned to an observation group and a control group by a random number table,with 53 cases in each group.The control group received labetalol hydrochloride,while the observation group received nitrendipine in combination with labetalol based on the control group until before delivery.The clinical efficacy,systolic blood pressure(SBP)and diastolic blood pressure(DBP)levels,maternal and infant perinatal outcomes,and incidence of adverse reactions in the two groups were compared.Results The total response rate in the control group was 77.36%,which was significantly lower than that in the observation group(94.34%;P<0.05).Before treatment,there was no significant difference in SBP and DBP between the two groups(P>0.05).After treatment,both SBP and DBP decreased in both groups,and the observation group was lower than the control group,with statistical significance(P<0.05).In addition,the incidence of premature delivery and cesarean section in the observation group was significantly lower than that in the control group(P<0.05).The incidence of fetal growth restriction and neonatal asphyxia in the observation group was also significantly lower than that in the control group(P<0.05).The incidence of adverse reactions such as rash and fatigue in the control group was 16.98%,which was higher than that in the observation group of 15.09%,but the difference was not statistically significant(P>0.05).Conclusion Labetalol combined with nitrendipine can effectively control the blood pressure of patients with GH,improve clinical efficacy,and enhance maternal and infant outcomes,with a high s

关 键 词：拉贝洛尔 硝苯地平 妊娠期高血压 联合用药 围生结局 

分 类 号：R714.246[医药卫生—妇产科学]