运动促进骨骼肌健康的新视角:基于Rac1/PAK1/p38 MAPK信号通路改善肌生成和糖代谢的研究进展与展望  

A New Perspective on Exercise Promoting Skeletal Muscle Health:Research Progress and Prospect of Improving Myogenesis and Glucose Metabolism Based on Rac1/PAK1/p38 MAPK Signaling Pathway

作　　者：任翔宇[1,2] 沈飞 金玲[1,2] 卢健 陈彩珍[1,2] REN Xiangyu;SHEN Fei;JIN Ling;LU Jian;CHEN Caizhen(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;College of Physical Education and Health,East China Normal University,Shanghai 200241,China;Institute of Physical Education,Jiangsu Normal University,Xuzhou 221116,China.)

机构地区：[1]华东师范大学“青少年健康评价与运动干预”教育部重点实验室,上海200241 [2]华东师范大学体育与健康学院,上海200241 [3]江苏师范大学体育学院,江苏徐州221116

出　　处：《中国体育科技》2023年第5期79-87,共9页China Sport Science and Technology

基　　金：教育部人文社会科学研究青年基金项目(22YJC890023);中国高等教育学会规划课题重点项目(22TY0218)。

摘　　要：骨骼肌是维持机体运动能力、调节机体能量代谢的重要器官,其内分泌功能也日益被重视。久坐、衰老、肥胖等因素会引起肌萎缩,继而影响糖脂代谢稳态,引起内分泌失调等相关疾病。抑制Rac1/PAK1/p38 MAPK信号通路能干预癌变,而激活该通路可控制骨骼肌生成、调节机体糖代谢。通过文献资料调研法分析了Rac1/PAK1/p38 MAPK信号通路的生理基础以及运动对其影响的可能性,系统阐述了运动调控Rac1/PAK1/p38 MAPK信号通路改善肌生成和糖代谢的潜在机制。研究认为,运动可通过Rac1/PAK1/p38 MAPK信号通路促进生肌决定因子的形成和葡萄糖转运蛋白4转位,从而促进骨骼肌再生,改善骨骼肌对葡萄糖的摄取能力。Skeletal muscle is an important organ for maintaining exercise ability and regulating energy metabolism,and its endocrine function is also increasingly valued.Sedentary,aging,obesity,and other factors can cause muscle atrophy,which in turn affects the homeostasis of glucolipid metabolism and causes endocrine dyscrasia and other related diseases.It has been found that inhibition of the Rac1/PAK1/p38 MAPK signaling pathway intervenes in carcinogenesis,and activation of this pathway controls skeletal muscle generation and regulates glucose metabolism in the body.Through literature research,this study analyzes the physiological basis of the Rac1/PAK1/p38 MAPK signaling pathway and the possibility of the effect of exercise on it,systematically elaborates the potential mechanisms of exercise regulation of the Rac1/PAK1/p38 MAPK signaling pathway to improve myogenesis and glucose metabolism.This study concluded that exercise promotes the formation of myogenic determinants and the translocation of glucose transporter type 4 through this pathway,thereby promoting muscle regeneration and improving the glucose-uptake ability of the skeletal muscle.

关 键 词：运动 Rac1/PAK1/p38 MAPK信号通路 骨骼肌 肌生成 糖代谢 

分 类 号：G804.2[文化科学—运动人体科学]