参芪十一味颗粒联合左甲状腺素钠片治疗脾肾阳虚型桥本甲状腺炎的效果  

Efficacy of Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets in the treatment of Hashimoto thyroiditis with syndrome of yang deficiency of spleen and kidney

作　　者：贾伟 王芬[1] 王灿 陆雅婷 郭文露 李晓蝶 朱德发[1] JIA Wei;WANG Fen;WANG Can;LU Yating;GUO Wenlu;LI Xiaodie;ZHU Defa(Department of Geriatric Endocrinology,the First Affiliated Hospital of Anhui Medical University,Anhui Province,Hefei230022,China;Department of Endocrinology and Metabolic Diseases,the First Affiliated Hospital of Anhui Medical University,Anhui Province,Hefei230022,China)

机构地区：[1]安徽医科大学第一附属医院老年内分泌科,安徽合肥230022 [2]安徽医科大学第一附属医院内分泌与代谢病学科,安徽合肥230022

出　　处：《中国医药导报》2023年第15期77-81,共5页China Medical Herald

基　　金：安徽省自然科学基金项目(1908085QH339)。

摘　　要：目的探究参芪十一味颗粒联合左甲状腺素钠片治疗脾肾阳虚型桥本甲状腺炎(HT)的效果。方法选取安徽医科大学第一附属医院2020年4月至2021年10月收治的脾肾阳虚型HT患者90例。按照随机数字表法将患者分为对照1、2组与治疗组,每组30例。对照1组给予左甲状腺素钠片,对照2组给予参芪十一味颗粒,治疗组给予左甲状腺素钠片联合参芪十一味颗粒。三组疗程均为3个月。比较三组临床疗效及治疗前后的中医症状评分、甲状腺激素指标、甲状腺抗体指标、炎症因子及淋巴细胞亚群水平。结果治疗组临床疗效优于对照1、2组(P<0.05)。治疗后,三组中医症状评分、抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体、促甲状腺激素、白细胞介素-6水平均低于治疗前,且治疗组低于对照1、2组(P<0.05)。治疗后,三组CD^(4)+/CD^(8)+水平均高于治疗前(P<0.05)。治疗后,三组游离三碘甲状腺原氨酸、游离甲状腺激素、CD^(3)+、CD^(4)+、CD^(8)+、白细胞介素-10水平均高于治疗前,且治疗组高于对照1、2组(P<0.05)。结论参芪十一味颗粒联合左甲状腺素钠片治疗脾肾阳虚型HT效果显著,可改善患者症状,降低炎症因子,维持免疫细胞稳定。Objective To explore the efficacy of Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets in the treatment of Hashimoto thyroiditis(HT)with syndrome of yang deficiency of spleen and kidney.Methods A total of 90 HT patients with syndrome of yang deficiency of spleen and kidney admitted to the First Affiliated Hospital of Anhui Medical University from April 2020 to October 2021 were selected.Patients were divided into control 1,2 groups,and treatment group according to random number table method,with 30 cases in each group.Control 1 group was given Levothyroxine Sodium Tablets,control 2 group was given Shenqi Shiyiwei Granules,treatment group was given Levothyroxine Sodium Tablets combined with Shenqi Shiyiwei Granules.The treatment course of the three groups was three months.The clinical efficacy and traditional Chinese medicine symptom scores,thyroid hormone indexes,thyroid antibody indexes,inflammatory factors,and lymphocyte subsets before and after treatment were compared among the three groups.Results The clinical efficacy of the treatment group was better than that of control 1 and 2 groups(P<0.05).After treatment,traditional Chinese medicine symptom scores,anti-thyroglobulin antibody,anti-thyroid peroxidase antibody,thyrotropin hormone,and interleukin-6 levels in the three groups were lower than those before treatment,and those in treatment group were lower than those in control 1 and 2 groups(P<0.05).After treatment,the CD^(4)+/CD^(8)+levels in three groups were higher than those before treatment(P<0.05).After treatment,the free triiodothyronine,free thyroid hormone,CD^(3)+,CD^(4)+,CD^(8)+,and interleukin-10 levels in three groups were higher than those before treatment,and those in treatment group were higher than those in control 1 and 2 groups(P<0.05).Conclusion Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets have significant effects in the treatment of HT with syndrome of yang deficiency of spleen and kidney,which can improve symptoms,reduce inflammatory factors,and ma

关 键 词：桥本甲状腺炎 参芪十一味颗粒 左甲状腺素钠片 淋巴细胞亚群 免疫功能 

分 类 号：R581.4[医药卫生—内分泌]