Nrf2调节氧化应激在糖尿病肾病中的作用机制  

The mechanism of Nrf2 regulating oxidative stress in diabetes nephropathy

作　　者：尹大鹏 郭志新[1] YIN Dapeng;GUO Zhixin(Department of Endocrinology,The Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第二医院内分泌科,山西太原030001

出　　处：《中国临床研究》2023年第5期646-650,共5页Chinese Journal of Clinical Research

基　　金：山西省回国留学人员科研资助项目(2020-192);山西省基础研究计划项目(自然科学研究面上项目)(202103021224414)。

摘　　要：氧化应激参与糖尿病肾病(DN)的发生,葡萄糖代谢异常会导致氧自由基的产生,损伤肾脏固有细胞,影响肾组织的结构和功能。同时高糖诱导的氧化应激抑制抗氧化因子核因子红系2相关因子(Nrf2)的表达,其激活对糖尿病小鼠肾脏具有保护作用,能够在细胞水平上改善肾损伤。但Nrf2参与DN的抗氧化机制目前仍未阐明,因此本文将介绍Nrf2在细胞水平上调节氧化应激改善高糖引起的肾损伤。Oxidative stress participates in the occurrence of diabetic nephropathy(DN).Abnormal glucose metabolism will lead to the production of oxygen free radicals,damaging the intrinsic cells of the kidney,affecting the structure and function of renal tissue.Meanwhile,the high glucose-induced oxidative stress inhibits the expression of the antioxidant factor Nrf2,which activation has a protective effect on the kidney of diabetic mice,and can improve the kidney injury at the cellular level.However,the antioxidant mechanism of Nrf2 involved in DN remains unclear.This paper will introduce the role of Nrf2 in regulating oxidative stress at the cellular level to improve renal injury caused by high glucose.

关 键 词：氧化应激 核因子红系2相关因子 糖尿病肾病 足细胞 系膜细胞 肾小球内皮细胞 肾小管 铁死亡 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]