微点阵激光联合雌三醇乳膏治疗绝经后压力性尿失禁  

Fractional micro ablative laser and estriol cream in the treatment ofpostmenopausal stress urinary incontinence

作　　者：王庆 袁文凤 李俊强 马多娜 许鑫玥 马婉莹 WANG Qing;YUAN Wenfeng;LI Junqiang;MA Duona;XU Xinyue;MA Wanying(Department of Gynecology and Obstetrics,Sichuan Jinxin Women&Children Hospital,Chengdu,Sichuan 610011,China;不详)

机构地区：[1]四川锦欣妇女儿童医院妇产科,四川成都610011 [2]西南交通大学附属医院成都市第三人民医院妇产科,四川成都610031

出　　处：《中国临床研究》2023年第5期693-697,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金(31500077);四川省卫生和计划生育委员会科研基金(17PJ254)。

摘　　要：目的探讨微点阵激光联合经阴道给予雌三醇乳膏治疗绝经后轻中度压力性尿失禁(SUI)的临床效果及安全性。方法选取2020年1月至2022年1月于四川锦欣妇女儿童医院及成都市第三人民医院诊治的220例绝经后轻中度SUI作为研究对象。按随机数字表法分为对照组和研究组,各110例。对照组采用微点阵激光治疗,研究组采用微点阵激光联合雌三醇乳膏治疗,共随访6个月。比较两组临床疗效,治疗前后1 h漏尿量、尿失禁症状评分、生活质量评分、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分,治疗及随访期间子宫内膜厚度变化及不良反应发生情况。结果对照组失访1例。研究组总有效率高于对照组(84.55%vs 73.39%,P<0.05),治疗后研究组1 h漏尿量少于对照组[(1.96±0.87)g vs(2.56±1.14)g,P<0.05],生活质量评分高于对照组(P<0.05),尿失禁症状评分、SAS、SDS评分低于对照组(P<0.05);两组治疗及随访期间子宫内膜厚度、不良反应发生率对比差异无统计学意义(P>0.05)。结论微点阵激光联合雌三醇乳膏治疗绝经后轻中度SUI疗效确切,较单用微点阵激光治疗总有效率更高,可显著改善患者生活质量,缓解焦虑抑郁状态,治疗间隔长,方便安全。Objective To investigate the efficacy and safety of fractional micro ablative laser combined with estriol cream in the treatment of postmenopausal mild to moderate stress urinary incontinence(SUI).Methods Postmenopausal patients(220 cases)with mild to moderate SUI in Sichuan Jinxin Women&Children Hostipal and the Third People's Hospital of Chengdu from January 2020 to January 2022 were randomly divided into the control group(n=110)and the study group(n=110).The patients in the control group were treated with fractional micro ablative laser,while the patients in the study group was additionally given estriol cream.The patients were followed up for 6 months.The clinical efficacy,1 h urine leakage,urinary incontinence symptom score,quality of life score,self-rating anxiety scale(SAS),self-rating depression scale(SDS)score,endometrial thickness changes and adverse reactions were compared between two groups.Results One patient was lost to follow-up in control group.Compared with control group,the total effective rate was higher(84.55%vs 73.39%,P<0.05),the 1 h urine leakage was less[(1.96±0.78)g vs(2.56±1.14)g,P<0.05],the quality of life score was higher,the scores of urinary incontinence symptoms,SAS and SDS were lower(P<0.05)in the study group.There was no significant difference in the incidence of adverse reactions and endometrial thickness during treatment and follow-up(P>0.05).Conclusion Fractional micro ablative laser combined with estriol cream in the treatment of mild to moderate postmenopausal SUI can improve the effective rate and the quality of life of patients,relieve anxiety and depression,have long treatment intervals,convenience and high safety.

关 键 词：微点阵激光 雌三醇乳膏 绝经后 压力性尿失禁 焦虑 抑郁 生活质量 

分 类 号：R694.54[医药卫生—泌尿科学]