绝经后慢性心力衰竭患者内源性性激素水平与左心室射血分数的相关性研究  

Study of correlation between endogenous sex hormone levels and left ventricular ejection fraction in postmenopausal patients with chronic heart failure

作　　者：张海洋[1] 冯静茹[2] 李凡 王静[1] 赵娜[1] 毕胜利[2] 李新军[1] ZHANG Haiyang;FENG Jingru;LI Fan;WANG Jing;ZHAO Na;BI Shengli;LI Xinjun(Department of Cardiology,the Second Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou075100,China;Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou075100,China;Department of Laboratory,the Second Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou075100,China)

机构地区：[1]河北北方学院附属第二医院心内科,河北张家口075100 [2]河北北方学院附属第二医院妇科,河北张家口075100 [3]河北北方学院附属第二医院检验科,河北张家口075100

出　　处：《中国医药导报》2023年第13期96-99,共4页China Medical Herald

基　　金：河北省卫生健康委员会医学科学研究课题计划项目(20190867)。

摘　　要：目的探究与分析绝经后慢性心力衰竭患者内源性性激素水平与左室射血分数(LVEF)的相关性。方法选取2019年3月至2021年10月于河北北方学院附属第二医院(以下简称“我院”)确诊为慢性心力衰竭的绝经住院患者125例为研究对象,将其按照美国纽约心脏病学会分级方案分为心功能Ⅱ级(34例)、Ⅲ级(42例)、Ⅳ级组(49例),同时选择我院收治的未发生心力衰竭的绝经患者30例为无心力衰竭组。收集并比较四组睾酮(T)、雌二醇(E_(2))、黄体生成素(LH)、促卵泡激素(FSH)、催乳素(PRL)、孕酮(PROG)及LVEF,进一步采用Spearman相关系数分析绝经后慢性心力衰竭患者内源性性激素水平与LVEF的相关性。结果心功能Ⅱ级、Ⅲ级、Ⅳ级组E_(2)、LVEF低于无心力衰竭组,PRL高于无心力衰竭组,心功能Ⅲ级、Ⅳ级组E_(2)、LVEF低于心功能Ⅱ级组,PRL高于心功能Ⅱ级组,心功能Ⅳ级组E_(2)、LVEF低于心功能Ⅲ级组,PRL高于心功能Ⅲ级组,差异有统计学意义(P<0.05)。相关性分析结果显示,绝经后慢性心力衰竭患者的E_(2)与LVEF呈正相关(r_(s)>0,P<0.05),PRL与LVEF呈负相关(r_(s)<0,P<0.05)。结论E_(2)、PRL水平与绝经后慢性心力衰竭患者的LVEF之间具有密切的相关性,对上述指标进行监测可为绝经后慢性心力衰竭患者心功能评估及判断提供参考依据。Objective To investigate and analyze the correlation between endogenous sex hormone levels and left ventricular ejection fraction(LVEF)in postmenopausal patients with chronic heart failure.Methods A total of 125 postmenopausal inpatients diagnosed with chronic heart failure in the Second Affiliated Hospital of Hebei North University(hereinafter referred to as“our hospital”)from March 2019 to October 2021 were selected as the study objects.According to the New York Heart Association cardiology grading scheme,they were divided into cardiac functionⅡ(34 cases),Ⅲ(42 cases),Ⅳ(49 cases)groups.At the same time,30 menopausal patients without heart failure admitted to our hospital were selected as the non-heart failure group.Testosterone(T),estradiol(E_(2)),luteinizing hormone(LH),follicle stimulating hormone(FSH),prolactin(PRL),progesterone(PROG),and LVEF in the four groups were collected and compared.Spearman correlation coefficient was further used to analyze the correlation between endogenous sex hormone levels and LVEF in postmenopausal patients with chronic heart failure.Results E_(2) and LVEF of cardiac functionⅡ,Ⅲ,andⅣgroups were lower than those of non-heart failure group,while PRL was higher than that of the non-heart failure group,E_(2) and LVEF in cardiac functionⅢandⅣgroups were lower than those in cardiac functionⅡgroup,while PRL was higher than those in cardiac functionⅡgroup,E_(2) and LVEF in cardiac functionⅣgroup were lower than those in cardiac functionⅢgroup,and PRL was higher than those in cardiac functionⅢgroup,the differences were statistically significant(P<0.05).Correlation analysis showed that E_(2) was positively correlated with LVEF in postmenopausal patients with chronic heart failure(r_(s)>0,P<0.05),while PRL was negatively correlated with LVEF(r_(s)<0,P<0.05).Conclusion There is a close correlation between E_(2),PRL levels,and LVEF in postmenopausal patients with chronic heart failure.Monitoring the above indexes can provide a reference for the evaluation and ju

关 键 词：绝经 女性 慢性心衰 内源性性激素 心功能 

分 类 号：R541[医药卫生—心血管疾病]