体检人群中血非高密度脂蛋白胆固醇与不同身体部位骨量水平的相关性  

Correlation between serum non-high density lipoprotein cholesterol and bone mass levels in different body parts in physical examination population

作　　者：李绒[1] 李敏 马聪[1] Li Rong;Li Min;Ma Cong(Department of Health Medicine,the Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese People′s Liberation Army General Hospital,Beijing 100853,China;Department of Health Management,General Hospital of Xinjiang Military Region of the Chinese People′s Liberation Army,Urumqi 830000,China)

机构地区：[1]解放军总医院第二医学中心健康医学科国家老年疾病临床医学研究中心,北京100853 [2]解放军新疆军区总医院健康管理科,乌鲁木齐830000

出　　处：《中华健康管理学杂志》2023年第5期362-367,共6页Chinese Journal of Health Management

基　　金：解放军总医院青年成长项目(QNC19045)。

摘　　要：目的探讨体检人群中非高密度脂蛋白胆固醇(Non-HDL-C)与不同部位骨量水平的关系。方法本研究是横断面研究,回顾性分析2016年6至9月在解放军总医院健康管理研究院就诊的595例体检者。采用双能X线骨密度仪测定腰1~4椎体(脊柱)、双股骨及平均骨密度,收集上述体检者基本信息、生化指标,分析各组分血脂成分(含Non-HDL-C)与骨量水平之间的差异。结果根据血脂分层,脊柱T值在甘油三酯(TG)组(-0.15±1.41比-0.38±1.35)、Non-HDL-C组(-1.01±0.74比-1.21±0.59,-1.04±0.73比-1.30±0.45,-1.07±0.71比-1.30±0.26)及低密度脂蛋白胆固醇(LDL-C)组(-1.01±0.71比-1.32±0.56)间差异均有统计学意义(均P<0.05),在其他血脂成分组和股骨T值在各组分血脂中差异均无统计学意义。脊柱T值在LDL-C≥3.4 mmol/L组明显减低,在Non-HDL-C组各分层差异均有统计学意义。在二元logistic回归分析中,所有血脂成分中,LDL-C≥3.4 mmol/L(OR=3.961,95%CI:1.310~11.974)及Non-HDL-C>4.1 mmol/L(OR=3.600,95%CI:1.035~12.524)是椎体骨量减少的危险因素(P<0.05)。结论体检人群血脂成分中TG、LDL-C和Non-HDL-C增高者易发生骨质异常,其中Non-LDL-C≥4.1 mmol/L和LDL-C≥3.4 mmol/L与椎体骨量减少的关系更为密切,是椎体骨量减少的危险因素。Objective To compare the relationship between non-high-density lipoprotein cholesterol(non-HDL-C)and bone mass in different body parts in the physical examination population.Methods It was a cross-sectional study.The data of 595 physical examiners who visited the Institute of Health Management,PLA General Hospital from June to September 2016 were retrospectively analyzed.The bone mass levels of lumbar 1-4 vertebral body(spine)and femur,average bone density were measured by double light energy X-ray bone density instrument.The basic information and biochemical indices of the physical examiners were collected.The difference between blood lipid components(including Non-HDL-C)and bone mass level of each body part were analyzed.Results According to blood lipid stratification,there were significant differences in spine T value(T-spine)between triglyceride(TG)groups(-0.15±1.41 vs-0.38±1.3),Non-HDL-C groups(-1.01±0.74 vs-1.21±0.59,-1.04±0.73 vs-1.30±0.45,-1.07±0.71 vs-1.30±0.26)and low-density lipoprotein cholesterol(LDL-C)groups(-1.01±0.71 vs-1.32±0.56)(all P<0.05).There was no statistically significant difference in other lipid groups and femoral T values in each component′s blood lipids.The T-spine decreased significantly in the LDL-C≥3.4 mmol/L group,and the differences were all significant among the Non-HDL-C group(all P<0.05).In binary logistic regression analysis,LDL-C≥3.4 mmol/L(OR=3.961,95%CI:1.310-11.974)and Non-HDL-C>4.1 mmol/L(OR=3.600,95%CI:1.035-12.524)were risk factors for vertebral bone mass loss(both P<0.05).Conclusion People with elevated serum TG,Non-HDL-C and LDL-C in the physical examination population are prone to bone abnormalities.Non-HDL-C≥4.1 mmol/L and LDL-C≥3.4 mmol/L are more closely related to the vertebral bone mass loss and are the risk factors for vertebral bone mass loss.

关 键 词：骨密度 血脂异常 非高密度脂蛋白胆固醇 骨质异常 骨量减少 

分 类 号：R68[医药卫生—骨科学]