益气活血化痰通络方联合纳洛酮治疗慢性阻塞性肺疾病合并肺性脑病临床研究  

Clinical Study on Yiqi Huoxue Huatan Tongluo Prescription Combined with Naloxone for Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Encephalopathy

作　　者：俞宁宁 葛金林 YU Ningning;GE Jinlin

机构地区：[1]温州市中西医结合医院呼吸内科,浙江温州325000

出　　处：《新中医》2023年第9期77-80,共4页New Chinese Medicine

摘　　要：目的:观察益气活血化痰通络方联合纳洛酮治疗慢性阻塞性肺疾病(COPD)合并肺性脑病的临床疗效。方法:将78例COPD合并肺性脑病患者按随机数字表法随机分为对照组与观察组各39例,对照组给予常规抗感染及纳洛酮治疗,观察组在对照组基础上联合益气活血化痰通络方治疗。比较2组治疗前后动脉血气指标及血清肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平,并比较2组临床疗效。结果:治疗前,2组动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))及动脉血pH值比较,差异无统计学意义(P>0.05);治疗3 d后,2组动脉PaO_(2)、动脉血pH值均上升(P<0.05),PaCO_(2)均下降(P<0.05),且观察组动脉PaO_(2)、动脉血pH值高于对照组(P<0.05),PaCO_(2)低于对照组(P<0.05)。治疗前,2组血清TNF-α、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组血清TNF-α、hs-CRP水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,观察组治疗总有效率89.74%,高于对照组71.79%(P<0.05)。结论:益气活血化痰通络方联合纳洛酮治疗COPD合并肺性脑病,可有效改善患者肺通气功能,抑制炎症反应,提高临床疗效。Objective:To observe the clinical effect of Yiqi Huoxue Huatan Tongluo Prescription combined with Naloxone for chronic obstructive pulmonary disease(COPD)complicated with pulmonary encephalopathy.Methods:A total of 78 cases of patients with COPD complicated with pulmonary encephalopathy were divided into the control group and the observation group according to the random number table method,with 39 cases in each group.The control group was treated with routine antiinfection and Naloxone,and the observation group was additionally treated with Yiqi Huoxue Huatan Tongluo Prescription based on the treatment of the control group.The arterial blood gas indexes,and the levels of tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in serum were compared before and after treatment between the two groups,and the clinical effects were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and arterial blood pH values between the two groups(P>0.05).After 3 days of treatment,the arterial PaO_(2)and arterial blood pH values in the two groups were increased(P<0.05),and PaCO_(2)was decreased(P<0.05);the arterial PaO_(2)and pH value in the observation group were higher than those in the control group(P<0.05),and PaCO_(2)was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of TNF-αand hs-CRP in serum between the two groups(P>0.05).After treatment,the levels of TNF-αand hs-CRP in serum in the two groups were decreased(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).After treatment,the total effective rate was 89.74%in the observation group,higher than that of 71.79%in the control group(P<0.05).Conclusion:Yiqi Huoxue Huatan Tongluo Prescription combined with Naloxone for COPD complicated with pulmon

关 键 词：慢性阻塞性肺疾病 肺性脑病 益气活血化痰通络方 纳洛酮 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]