小儿咳喘灵颗粒与阿奇霉素联用治疗小儿支气管肺炎临床研究  

Clinical Study on Xiao'er Kechuanling Granules Combined with Azithromycin for Bronchopneumonia in Children

作　　者：王芝芳 时怡 金国萍 WANG Zhifang;SHI Yi;JIN Guoping

机构地区：[1]绍兴市柯桥区妇幼保健院,浙江绍兴312030

出　　处：《新中医》2023年第9期148-151,共4页New Chinese Medicine

摘　　要：目的:观察小儿咳喘灵颗粒与阿奇霉素联用治疗小儿支气管肺炎的临床效果。方法:将98例小儿支气管肺炎患儿按随机数字表法分为单一组49例和联用组49例。单一组采用阿奇霉素治疗,联用组在单一组基础上采用小儿咳喘灵颗粒治疗。比较2组临床疗效,比较2组治疗前后炎症因子水平以及肺功能指标。结果:联用组治疗总有效率91.84%,高于对照组71.43%(P<0.05)。治疗前,2组血清白细胞介素-6(IL-6)、降钙素原(PCT)、C-反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清IL-6、PCT、CRP水平均降低(P<0.05),且联用组低于单一组(P<0.05)。治疗前,2组呼气流量峰值(PEF)、第1秒用力呼气容积(FEV1)及用力肺活量(FVC)水平比较,差异无统计学意义(P>0.05)。治疗后,2组PEF、FEV1、FVC水平均上升(P<0.05),且联用组高于单一组(P<0.05)。结论:小儿咳喘灵颗粒与阿奇霉素联用治疗小儿支气管肺炎疗效显著,可有效降低炎症因子水平,促进肺部炎症吸收,恢复肺功能。Objective:To observe the clinical effect of Xiao'er Kechuanling Granules combined with Azithromycin for bronchopneumonia in children.Methods:A total of 98 cases of children with bronchopneumonia were divided into the single group and the combination group according to the random number table method,with 49 cases in each group.The single group was treated with Azithromycin,and the combination group was additionally treated with Xiao'er Kechuanling Granules based on the treatment of the single group.The clinical effects in the two groups were compared.Before and after treatment,the levels of inflammatory factors and lung function indexes in the two groups were compared.Results:The total effective rate of treatment was 91.84%in the combination group,higher than that of 71.43%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of interleukin-6(IL-6),procalcitonin(PCT),and C-reactive protein(CRP)in serum between the two groups(P>0.05).After treatment,the levels of IL-6,PCT,and CRP in serum in the two groups were decreased(P<0.05),and the levels in the combination group were lower than those in the single group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of peak expiratory flow(PEF),forced expiratory volume in one second(FEV1)and forced vital capacity(FVC)between the two groups(P>0.05).After treatment,the levels of PEF,FEV1,and FVC in the two groups were increased(P<0.05),and the levels in the combination group were higher than those in the single group(P<0.05).Conclusion:Xiao'er Kechuanling Granules combined with Azithromycin for bronchopneumonia in children has a significant curative effect,which can effectively reduce the levels of inflammatory factors,promote the absorption of lung inflammation and restore the lung function.

关 键 词：小儿支气管肺炎 小儿咳喘灵颗粒 阿奇霉素 炎症因子 肺功能 

分 类 号：R725.6[医药卫生—儿科]