温针灸治疗风寒湿痹型膝骨关节炎临床疗效及对血清疼痛介质水平的影响  

Clinical Effect of Warming-Needle Moxibustion for Knee Osteoarthritis of Wind-Cold and Fixed Impediment Type and Its Effect on Levels of Serum Pain Mediators

作　　者：王璐[1,2] 沈慈敏 华丹芸 WANG Lu;SHEN Cimin;HUA Danyun

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]宁波市奉化区中医医院医共体针推康复科,浙江宁波315500

出　　处：《新中医》2023年第9期187-190,共4页New Chinese Medicine

摘　　要：目的:观察温针灸治疗风寒湿痹型膝骨关节炎的临床疗效及对血清疼痛介质水平的影响。方法:将98例风寒湿痹型膝骨关节炎患者随机分为对照组与观察组各49例。对照组口服塞来昔布胶囊治疗,观察组在对照组基础上联合温针灸治疗。比较2组治疗前后疼痛视觉模拟评分法(VAS)评分、骨关节炎指数量表(WOMAC)评分、中医证候积分以及血清前列腺素E2(PGE2)、P物质(SP)、五羟色胺(5-HT)等疼痛介质水平。结果:治疗前,2组WOMAC评分、VAS评分比较,差异无统计学意义(P>0.05);治疗后,2组WOMAC评分、VAS评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组关节僵硬、关节冷痛、活动受限等中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组上述中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组血清PGE2、SP、5-HT水平比较,差异无统计学意义(P>0.05);治疗后,2组血清PGE2、SP、5-HT水平均下降(P<0.05),且观察组低于对照组(P<0.05)。结论:温针灸联合塞来昔布胶囊治疗风寒湿痹型膝骨关节炎可以有效降低血清疼痛介质水平,显著缓解疼痛等临床症状,具有较好的治疗效果。Objective:To observe the clinical effect of warming-needle moxibustion on knee osteoarthritis of wind-cold and fixed impediment type and its effects on levels of serum pain medicators.Methods:A total of 98 patients with knee osteoarthritis of wind-cold and fixed impediment type were randomly divided into two groups,with 49 cases in each group.The control group was given oral administration of Celecoxib Capsules,and the observation group was additionally treated with warmingneedle moxibustion based on the treatment of the control group.Before and after treatment,the scores of Visual Analogue Scale(VAS)for pain and Western Ontario and McMaster University Osteoarthritis Index(WOMAC),traditional Chinese medicine(TCM)syndrome scores and levels of pain mediators,including serum prostaglandin E2(PGE2),substance P(SP)and 5-hydroxytryptamine(5-HT)were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparisons of scores of WOMAC and VAS between the two groups(P>0.05);after treatment,the scores of WOMAC and VAS in both groups were decreased(P<0.05),and the above two scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores of stiff joints,cold pain in joints and limited joint movement between the two groups(P>0.05);after treatment,the above three TCM syndrome scores in the two groups were decreased(P<0.05),and the above three TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of levels of serum PGE2,SP and 5-HT between the two groups(P>0.05);after treatment,the levels of serum PGE2,SP and 5-HT in both groups were decreased(P<0.05),and the above three levels in the observation group were lower than those in the control group(P<0.05).Conclusion:Warming-needle moxibustion combined with Celecoxib Capsules for

关 键 词：膝骨关节炎 温针灸 风寒湿痹 疼痛介质 非甾体抗炎药 

分 类 号：R246.9[医药卫生—针灸推拿学]