不同提取工艺对复方银杏通脉口服液质量指标的影响  

Influence of different extraction processes on quality indices of Compound Yinxing Tongmai oral liquid

作　　者：吕珍珍 邹奇 杨勇 侯凤飞[1,2] LYU Zhenzhen;ZOU Qi;YANG Yong;HOU Fengfei(Hunan Busky Pharmaceutical Co.,Ltd.,Huaihua 418400,Hunan,China;Hunan Provincial Engineering Research Center of Poria cocos,Huaihua 418400,Hunan,China;Hunan University of Chinese Medicine,Changsha 410208,Hunan,China)

机构地区：[1]湖南补天药业股份有限公司,湖南怀化418400 [2]湖南省茯苓工程技术研究中心,湖南怀化418400 [3]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医杂志》2023年第4期190-196,共7页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省科技创新计划项目(2020SK2051);湖南省怀化市科技计划项目(2019zh010585)。

摘　　要：目的:探讨不同提取工艺对复方银杏通脉口服液质量指标的影响。方法:采用微波提取、超声提取、醇与水回流提取3种工艺,通过正交试验法对复方银杏通脉口服液的处方进行提取,以总黄酮醇苷、二苯乙烯苷、丹酚酸B含量及干膏率作为考察指标,运用综合评分法进行质量指标的比较。结果:最佳工艺为醇与水回流提取,12倍量料液比,回流提取1 h,提取2次。结论:醇与水回流提取工艺优于微波提取及超声提取工艺,且该方法实际可行,成本可控,可实现大生产。Objective:To investigate the influence of different extraction processes on the quality indices of Compound Yinxing Tongmai oral liquid.Methods:Based on an orthogonal design,the prescription of Compound Yinxing Tongmai oral liquid was extracted using microwave extraction,ultrasound extraction,and alcohol-water reflux extraction.With total flavonoid glycosides,stilbene glucoside,salvianolic acid B,and dry extract yield as the indicators for assessment,the comprehensive score method was used for comparison of quality indices.Results:The optimal process was alcohol-water reflux extraction,with a solid-liquid ratio of 12 folds,reflux extraction for 1 hour,and extraction twice.Conclusion:Alcohol-water reflux extraction is better than microwave extraction and ultrasound extraction and is practical and feasible with controllable costs,and therefore,it can be used to realize mass production.

关 键 词：复方银杏通脉口服液 提取工艺 质量指标 实验研究 

分 类 号：R284.2[医药卫生—中药学]