注射用磷酸肌酸钠联合阿米卡星在心力衰竭合并细菌性肺炎患者中的应用效果  

Effect of sodium phosphate creatine for injection combined with amikacin in patients with heart failure complicated with bacterial pneumonia

作　　者：洪春霞 马闪珊 吕世文 HONG Chunxia;MA Shanshan;LYU Shiwen(Department of Pharmacy,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Jinghua 321000,China)

机构地区：[1]浙江大学医学院附属金华医院药学部,321000

出　　处：《心电与循环》2023年第3期235-239,共5页Journal of Electrocardiology and Circulation

摘　　要：目的探讨注射用磷酸肌酸钠联合阿米卡星治疗心力衰竭合并细菌性肺炎患者的效果。方法选择2019年3月至2021年3月浙江大学医学院附属金华医院收治的82例心力衰竭合并细菌性肺炎患者为研究对象,其中予注射用磷酸肌酸钠联合阿米卡星治疗41例,为观察组;仅阿米卡星治疗41例,为对照组。治疗2周后,观察并比较两组患者肺炎疗效,症状改善时间,心功能指标[包括左心室射血分数(LVEF)、左心室收缩末期内径(LVESd)、左心室舒张末期内径(LVEDd)],应激状态指标[包括丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)],血清降钙素原(PCT)、C反应蛋白(CRP)、N末端脑钠肽前体(NT-proBNP)水平变化,药物不良反应发生率等。结果观察组总有效率明显高于对照组(P<0.05),退热、咳嗽消失、气喘消失、肺部湿啰音消失时间均明显短于对照组(均P<0.05)。两组患者治疗前LVEF、LVESd、LVEDd以及血清MDA、GSH-Px、SOD、PCT、CRP、NT-proBNP水平比较,差异均无统计学意义(均P>0.05);治疗2周后观察组LVEF以及血清GSH-Px、SOD水平均明显高于对照组(均P<0.05),LVESd、LVEDd以及血清MDA、PCT、CRP、NT-proBNP水平均明显低于对照组(均P<0.05)。两组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论注射用磷酸肌酸钠联合阿米卡星治疗心力衰竭合并细菌性肺炎安全有效,能有效缓解患者临床症状,改善心功能,减轻应激反应,降低血清PCT、CRP、NT-proBNP水平。Objective To investigate the effect of sodium phosphate creatine for injection combined with amikacin in the treatment of patients with heart failure complicated with bacterial pneumonia.Methods A total of 82 patients with heart failure complicated with bacterial pneumonia in Affiliated Jinhua Hospital,Zhejiang University School of Medicine from March 2019 to March 2021 were selected as the research subjects,of which 41 patients were treated with sodium phosphate creatine for injection combined with amicacin.Only amikacin was used to treat 41 cases as control group.After 2 weeks of treatment,pneumonia efficacy,symptom improvement time,cardiac function indexes[including left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd)]of the two groups were observed and compared.Stress state indicators[including malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)],serum levels of procalcitonin(PCT),C-reactive protein(CRP),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level changes,drug adverse reactions,etc.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05),and the time for fever,cough,asthma and lung wet rales disappearance were significantly shorter than those of the control group(all P<0.05).There were no significant differences in the levels of LVEF,LVESd,LVEDd,serum MDA,GSH-Px,SOD,PCT,CRP and NT-proBNP between the 2 groups before treatment(all P>0.05).After 2 weeks of treatment,the levels of LVEF,serum GSH-Px and SOD in the observation group were significantly higher than those in the control group(all P<0.05),while the levels of LVESd,LVEDd,serum MDA,PCT,CRP and NT-proBNP in the observation group were significantly lower than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse drug reactions between the 2 groups(P>0.05).Conclusion Creatine phosphate sodium combined with amikacin for injecti

关 键 词：注射用磷酸肌酸钠 阿米卡星 心力衰竭 细菌性肺炎 心功能 应激 

分 类 号：R541.6[医药卫生—心血管疾病] R563.1[医药卫生—内科学]