喜炎平联合二代青霉素治疗猩红热疗效及对A族链球菌阳性率的影响  

The Effect of Xiyanping Combined with Second-generation Penicillin on Scarlet Fever and the Positive Rate of Group A Streptococci

作　　者：李颖爽 李忠正 袁立秋 LI Ying-shuang;LI Zhong-zheng;YUAN Li-qiu(Department of Infectious Diseases,Jilin Children's Hospital,Jilin Jilin 132011,China)

机构地区：[1]吉林市儿童医院感染性疾病科,吉林吉林132011

出　　处：《中华养生保健》2023年第12期47-50,共4页CHINESE HEALTH CARE

摘　　要：目的探讨喜炎平联合二代青霉素治疗猩红热疗效及对A族链球菌阳性率的影响。方法选取2017年1月—2020年12月吉林市儿童医院收治的100例猩红热患儿作为研究对象,应用随机数表法分为对照组和观察组,每组50例。对照组患儿进行常规静脉滴注一代青霉素,观察组采取二代青霉素联合喜炎平静脉滴注,比较两组患者的临床疗效、治疗后患儿的睡眠质量评分、猩红热症状评分、症状改善及痊愈时间、治疗前后A族链球菌阳性率以及不良反应情况。结果治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿的GAS菌株和SpeC、SpeA菌株阳性表达情况明显降低,且观察组较对照组更低,差异有统计学意义(P<0.05)。治疗前,两组的睡眠质量评分、猩红热症状评分比较,差异无统计学意义(P>0.05);治疗后,两组以上两项指标评分都有明显下降的趋势,且观察组评分低于对照组,差异有统计学意义(P<0.05)。同时观察组患儿痊愈时间与症状改善时间也明显低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论喜炎平联合二代青霉素治疗猩红热疗效显著,能够降低A族链球菌阳性率,快速减轻患儿临床症状,使睡眠质量得到提高,同时其也有较高的安全性,在临床上有一定的应用价值,值得临床应用。Objective To investigate the efficacy of Xiyanping combined with second-generation penicillin in the treatment of scarlet fever and the effect on the positive rate of group A streptococcus.Methods 100 children with scarlet fever admitted to Jilin Children's Hospital from January 2017 to December 2020 were selected as the research object,and were divided into two groups with 50 cases in each group by random number table method.The children in the control group received routine intravenous drip of the first generation penicillin,while the children in the observation group received intravenous drip of the second generation penicillin combined with Xiyanping to compare the clinical efficacy of the two groups,the sleep quality score,scarlatina symptom score,symptom improvement and recovery time of the children after treatment,and the positive rate of group A streptococci before and after treatment and adverse reactions.Results After treatment,the total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the positive expression of GAS strain,SpeC strain and SpeA strain of emm gene in the two groups decreased significantly,and the positive expression in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no difference in sleep quality scores and scarlet fever symptoms between the two groups before treatment,the difference was not statistically significant(P>0.05).After treatment,the scores of the above two indicators in the two groups had a significant downward trend,and the scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).At the same time,the recovery time and symptom improvement time of the children in the observation group were also significantly lower than those in the control group,and the difference was statistically significant(P<0.05).There was no diffe

关 键 词：喜炎平 二代青霉素 猩红热 急性呼吸道感染 A族链球菌 不良反应 

分 类 号：R515[医药卫生—内科学]