钾离子结合药物研究进展  

Research Progress of Potassium Binders

作　　者：张慧杰 陈晓旭[3] 王芳宇[1,2] 刘燕 梁颖[1,2] 孙浩[1,2] ZHANG Hui-jie;CHEN Xiao-xu;WANG Fang-yu;LIU Yan;LIANG Ying;SUN Hao(Pharmaceutical Department,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China;Chinese Medicine Research Institute,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津市中医药研究院附属医院药学部,天津300120 [2]天津中医药研究院附属医院中药研究所,天津300120 [3]天津中医药大学第一附属医院药学部,天津300193

出　　处：《中国药学杂志》2023年第8期658-667,共10页Chinese Pharmaceutical Journal

基　　金：国家重点研发计划项目资助(2017YFC1703400);天津市卫生健康委员会、天津市中医药管理局中医中西医结合科研课题青年项目资助(2019025);天津市中医药研究院附属医院科研培育基金项目资助(2020003)。

摘　　要：钾离子(K^(+))是维持人体生理机能的重要阳离子。高钾血症除引起肌肉抽搐、麻痹外,可诱发多种类型心律失常,严重者导致猝死,并可增加慢性肾脏病、心力衰竭等疾病患者的死亡风险。K^(+)结合药物可通过结合肠道内K^(+)、并促进其肠道排泄而达到降低血钾水平的目的,是降低及控制血钾的重要方法。这类药物包括阳离子交换树脂(聚苯乙烯磺酸钠,聚苯乙烯磺酸钙)及新型K^(+)结合药物(环硅酸锆钠,patiromer)。笔者通过检索国内外相关文献,对上述K^(+)结合药物的特点、临床有效性以及安全性等方面进行综述,以期为这类药物的深入研究及合理使用提供参考。Potassiumion(K^(+))is an important cation to maintain human physiological function.In addition to causing muscle convulsions and paralysis,hyperkalemia can induce various types of arrhythmias,resulting in sudden death in severe cases,and increasing the risk of death in patients with chronic kidney diseaseand heart failure.K^(+)binders can reduce blood potassium level by binding K^(+)in intestinal tract and promoting intestinal excretion of K^(+),which is an important method to reduce and control blood potassium level.K^(+)binders includes cation exchange resins(sodium polystyrene sulfonate,calcium polystyrene sulfonate)and novel K^(+)binders(sodium zirconium cyclosilicate,patiromer).In this paper,the characteristics,clinical effectiveness and safety of the above-mentioned K^(+)binders are reviewed by searching relevant literature at home and abroad,in order to provide information for in-depth research and rational use of these drugs.

关 键 词：钾离子 聚苯乙烯磺酸钠 聚苯乙烯磺酸钙 环硅酸锆钠 patiromer 

分 类 号：R972[医药卫生—药品]