左乙拉西坦群体药动学系统分析  

A Systematic Review of Population Pharmacokinetics of Levetiracetam

作　　者：李莹[1] 王鸣璐 王成彬 赵明明[1] 肇丽梅[1] LI Ying;WANG Ming-lu;WANG Cheng-bin;ZHAO Ming-ming;ZHAO Li-mei(Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《中国药学杂志》2023年第7期632-637,共6页Chinese Pharmaceutical Journal

基　　金：盛京自由研究者基金资助(M0779)。

摘　　要：目的 对左乙拉西坦(levetiracetam, LEV)的群体药动学(population pharmacokinetic, PPK)研究进行系统分析,并探讨影响LEV药动学行为的因素。方法 通过检索中国知网、万方、维普、Embase和Pubmed等中英文文献数据库,收集采用非线性混合效应模型方法进行建模的PPK研究。结果 共纳入17项研究,其中15项研究采用一室结构模型进行建模。体重和肾功能是影响LEV药动学最常见的两种协变量。对于模型评价,仅有4项研究采用了外部评价。结论 LEV的药动学变异主要受体重和肾功能影响。当在目标人群中应用模型时,有必要对模型进行外部评价。现有研究对于利用PPK方法评估LEV在肾清除增强、新生儿和妊娠期癫痫患者等特殊人群中的药动学行为尚有不足,需要进一步的深入研究。OBJECTIVE To review systematically the population pharmacokinetic(PPK)study of levetiracetam(LEV)and explore the affecting factors of LEV pharmacokinetic parameters.METHODS The PPK studies using nonlinear mixed effect model method were collected by searching CNKI,Wanfang,VIP,Embase and PubMed.RESULTS A total of 17 studies were included,among which 15 studies characterized LEV pharmacokinetics as a one-compartment model structure.The two most frequently identified significant covariates influencing LEV pharmacokinetics included weight and renal function.For model verification,only 4 studies used external evaluation.CONCLUSION Pharmacokinetic variability of LEV is dependent on the weight and renal function.The generalizability of these PPK models should be externally assessed.Existing studies are insufficient to evaluate the pharmacokinetic behavior of LEV in special populations such as enhanced renal clearance,neonatal and gestational epilepsy patients using PPK method,and further research is needed.

关 键 词：左乙拉西坦 群体药动学 非线性混合效应模型 

分 类 号：R969.1[医药卫生—药理学]