新型冠状病毒奥密克戎变异株感染者消化系统症状及腹部计算机断层扫描特征  

Characteristics of digestive system symptoms and abdominal computed tomography imaging of patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant

作　　者：郭严 刘凯军 文良志 王涛 石洁 张巧 冀晓洁 贾佳丽 肖世莉 陈东风 Guo Yan;Liu Kaijun;Wen Liangzhi;Wang Tao;Shi Jie;Zhang Qiao;Ji Xiaojie;Jia Jiali;Xiao Shili;Chen Dongfeng(Department of Gastroenterology,Army Medical Center of PLA(Chongqing Daping Hospital),Chongqing 400042,China)

机构地区：[1]解放军陆军特色医学中心(重庆大坪医院)消化内科,重庆400042

出　　处：《中华消化杂志》2023年第2期112-116,共5页Chinese Journal of Digestion

摘　　要：目的探讨新型冠状病毒奥密克戎变异株感染人群消化系统症状特征与核酸阳性持续时间的关系,分析奥密克戎变异株感染患者的腹部计算机断层扫描(CT)特征。方法对2022年4月11日至5月23日上海国家会展中心方舱医院收治的奥密克戎变异株感染患者进行调查问卷,问卷内容包括基本信息、核酸阳性起始时间、消化系统症状和转归等。结合患者病史资料统计消化道症状相关特征并分析其与核酸阳性持续时间的关系。对于核酸持续阳性时间≥10 d的患者进行胸腹部CT检查,分析其腹部CT特征及其与核酸阳性持续时间的关系。统计学方法采用独立样本t检验和多因素logistic回归模型。结果共收集4 360份有效问卷。4 360例患者中,男2 475例,女1 885例,住院时间为(6.8±4.9) d。4 360例患者中,1 979例(45.4%)出现食欲下降、腹部不适或腹痛、便秘、腹泻等消化道症状,有消化道症状患者的核酸阳性持续时间为(7.4±5.5) d,长于无消化道症状患者的核酸阳性持续时间[(6.5±3.6) d],差异有统计学意义(t=3.78,P<0.001)。在方舱医院隔离期间,消化道症状完全缓解的患者核酸阳性持续时间短于完全无缓解的患者[(7.3±5.2) d比(8.5±5.7) d],差异有统计学意义(t=2.25,P=0.025)。多因素logistic回归分析显示,患者合并消化道症状是核酸阳性持续时间≥10 d的独立危险因素(OR=1.316,95%置信区间1.294~2.205,P=0.046)。299例核酸阳性持续时间≥10 d患者中有187例(62.5%)伴消化道症状,146例(48.8%)患者腹部CT检查观察到胃十二指肠壁增厚、小肠壁增厚、小肠系膜血管模糊和结肠扩张积气等影像学改变。在核酸阳性持续时间≥10 d的患者中,腹部CT检查提示有胃肠道影像学改变患者的核酸阳性持续时间长于无胃肠道影像学改变的患者[(16.0±2.8) d比(13.0±2.1) d],差异有统计学意义(t=2.62,P=0.009)。结论奥密克戎变异株感染患者合并消化道�Objective To investigate the characteristics of digestive system symptoms and its relation with the time of nucleic acid continuous positive in population infected with severe acute respiratory syndrome coronavirus 2 Omicron variant,and to analyze the abdominal computed tomography(CT)features of patients infected with Omicron variant.Methods From April 11 to May 23,2022,a questionnaire survey was conducted in patients infected with Omicron variant admitted to the Shanghai National Convention and Exhibition Center Fangcang Hospital.The questionnaire included basic information,the start time of nucleic acid positive,respiratory symptoms,digestive system syptoms and outcomes,etc.Combined with the clinical data,the relation between digestive tract symptoms and the time of nucleic acid continuous positive were analyzed.Thoracic and abdominal CT were performed for patients with continuous positive nucleic acid results≥10 d,and the relationship between the abdominal CT imaging characteristics and the time of nucleic acid continuous positive was analyzed.Independent sample t-test and multivariate logistic regression were used for statistical analysis.Results A total of 4360 valid questionnaires were collected,including 2475 males and 1885 females,with a hospital stay of(6.8±4.9)d.Among the 4360 patients,1979 patients(45.4%)had gastrointestinal symptoms such as loss of appetite,abdominal discomfort or pain,constipation and diarrhea.The time of nucleic acid continuous positive in patients with gastrointestinal symptoms was(7.4±5.5)d,which was longer than that of patients without gastrointestinal symptoms(6.5±3.6)d,and the difference was statistically significant(t=3.78,P<0.001).During the isolation period in the Fangcang Hospital,the time of nucleic acid continuous positive in patients with complete remission of digestive tract symptoms was shorter than that of patients with no remission of digestive tract symptoms((7.3±5.2)d vs.(8.5±5.7)d),and the difference was statistically significant(t=2.25,P=0.025).The results

关 键 词：体征和症状 消化系统 体层摄影术 X线计算机 新型冠状病毒 奥密克戎变异株 

分 类 号：R511[医药卫生—内科学]