尖吻蝮蛇血凝酶对照氨甲环酸氯化钠防治围手术期失血有效性的真实世界研究  

Effectiveness of haemocoagulase agkistrodon versus tranexamic acid and sodium chloride in the prevention and treatment of perioperative bleeding:a real-world study

作　　者：吕金津 宣建伟 LV Jinjin;XUAN Jianwei(Health Economic Research Institute,School of Pharmaceutical Sciences,SunYat-sen University,Guangzhou 510006,P.R.China)

机构地区：[1]中山大学药学院医药经济研究所,广州510006

出　　处：《中国循证医学杂志》2023年第5期513-516,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的比较尖吻蝮蛇血凝酶和氨甲环酸氯化钠在真实世界中用于住院患者围手术期止血的有效性。方法根据溯直医疗数据库(SuValue^(■))中2016年1月1日至2020年12月31日使用尖吻蝮蛇血凝酶或氨甲环酸氯化钠的就诊记录构建研究型数据库。按不同干预措施将患者分别纳入研究组和对照组,进行1∶1倾向性评分匹配,比较两组的有效性差异。结果两组各纳入858例患者,两组患者的基线特征无统计学差异(P>0.05)。研究结果显示,尖吻蝮蛇血凝酶组患者的住院时长、红细胞压积下降值、平均估计手术出血量、血红蛋白下降值均低于氨甲环酸氯化钠组,差异具有统计学意义(P<0.01)。结论基于当前真实世界证据,尖吻蝮蛇血凝酶在住院患者围手术期止血的有效性优于氨甲环酸氯化钠。Objective To compare the effectiveness of haemocoagulase agkistrodon and tranexamic acid and sodium chloride in the prevention and treatment of perioperative bleeding in a real world setting.Methods A research database was constructed based on the records of inpatient visits using haemocoagulase agkistrodon and tranexamic acid and sodium chloride according to the SuValue^(■)database from January 1,2016 to December 31,2020.The patients were divided into two groups according to the different interventions.After matching with a 1∶1 propensity score,the effectiveness of two groups was compared.Results A total of 858 patients were included in each of the two groups,and there was no statistically significant difference in baseline characteristics between the two groups(P>0.05).Research results showed that patients using haemocoagulase agkistrodon had significantly reduced length of hospital stay,decrease in hematocrit,average estimated surgical bleeding,and decrease in hemoglobin(P<0.01).Conclusion Haemocoagulase agkistrodon has better effectiveness than tranexamic acid and sodium chloride for reducing perioperative blood loss based on current real world evidence.

关 键 词：真实世界研究 倾向性评分匹配 尖吻蝮蛇血凝酶 氨甲环酸氯化钠 围手术期失血 有效性 

分 类 号：R619.1[医药卫生—外科学]