中药复方制剂治疗艾滋病的临床研究证据图分析  

Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations:an evidence map analysis

作　　者：沙茵茵 徐立然[2] 王雪婷 邵灿灿[1] SHA Yinyin;XU Liran;WANG Xueting;SHAO Cancan(Henan University of Chinese Medicine,Zhengzhou 450000,P.R.China;The First Affiliated Hospital of Henan University of TCM,Zhengzhou 450008,P.R.China;Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi’an 710000,P.R.China)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院,郑州450008 [3]陕西省中医医院,西安710000

出　　处：《中国循证医学杂志》2023年第5期583-587,共5页Chinese Journal of Evidence-based Medicine

基　　金：国家“十三五”科技重大专项(编号:2017ZX10205502);国家自然科学基金项目(编号:U1604287);世界中医药学会联合会项目(编号:SCM NP 2021-0120)。

摘　　要：目的系统检索并运用证据图梳理中药复方制剂治疗艾滋病的临床研究,了解该领域证据分布情况。方法计算机检索CNKI、WanFang Data、VIP、CBM、PubMed和Cochrane Library数据库,搜集中药复方制剂治疗艾滋病的相关临床研究,检索时限均为建库至2022年8月。采用图表结合文字的方式分析并呈现证据分布特征。结果最终纳入文献337篇,包括268篇干预性研究、66篇观察性研究、4篇系统评价/Meta分析。共获得92种中药复方制剂,不同药物文献量分层明显,以康爱保生制剂报道频次最高。近年来发文量呈下降趋势,大部分文献质量偏低,证据等级不高。对于干预时间,本领域均倾向于较长的干预观察时间,对于结局指标,存在部分指标评价标准不统一,中医特色优势体现不明确的问题。系统评价/Meta分析数量与质量均呈现不足状态,尚未形成中药复方制剂治疗艾滋病的规范性共识、指南。结论中药复方制剂治疗艾滋病有效性和安全性方面的研究已初步形成一定规模的证据群。未来需进一步提高研究质量,发掘能够体现中医疗效优势的结局指标,规范制订相关临床指南。Objective To systematically search and sort out the clinical research literature on the treatment of AIDS by traditional Chinese medicine compound preparations by using the evidence map method,and to understand the distribution of evidence in this field.Methods The CNKI,WanFang Data,VIP,CBM,PubMed and Cochrane Library databases were electronically searched to collect studies on the treatment of AIDS with traditional Chinese medicine compound preparations from inception to August 2022.The distribution characteristics of evidence were analyzed and presented in the form of charts and words.Results A total of 337 articles were included,involving 268 intervention studies,66 observational studies and 4 systematic reviews/meta-analysis.A total of 92 kinds of traditional Chinese medicine compound preparations were obtained,and the literature quantity of different preparations was obviously stratified,with Kangaibaosheng preparation being the most frequently reported.In recent years,the number of published literature has been declining,the quality of literature is generally low,and the level of evidence is not high.As for the intervention duration,this field tends to have a longer intervention observation period.As for the outcome indicators,the evaluation criteria of some indicators are not uniform,and the characteristics of TCM advantages are not reflected.The quantity and quality of systematic reviews/meta-analyses were insufficient.No normative consensus or guidelines for the treatment of AIDS with traditional Chinese medicine compound preparations had been formed.Conclusion studies on the effectiveness and safety of traditional Chinese medicine compound preparations in treating AIDS has initially formed a certain scale of evidence group.In the future,it is necessary to further improve the quality of studies,explore outcome indicators that can reflect the advantages of TCM efficacy,and formulate relevant guidelines in a standardized manner.

关 键 词：中药复方制剂 艾滋病 临床研究 证据图 

分 类 号：R259[医药卫生—中西医结合]