围绝经期女性代谢综合征与高尿酸血症的相关性研究  

Correlation between metabolic syndrome and hyperuricemia in perimenopausal women

作　　者：普惠婕 卢双艳 毛勇 陈洁 张梅 李梦启 周佳 王松梅 孙承欢 叶爱芳 Pu Huijie;Lu Shuangyan;Mao Yong;Chen Jie;Zhang Mei;Li Mengqi;Zhou Jia;Wang Songmei;Sun Chenghuan;Ye Aifang(School of Public Health,Kunming Medical University,Kunming 650500,China;Health Management Center,Anning Traditional Chinese Medicine Hospital,Anning 650300,China)

机构地区：[1]昆明医科大学公共卫生学院,650500 [2]云南省安宁市中医医院健康管理中心,650300

出　　处：《中华内分泌代谢杂志》2023年第4期305-309,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：昆明医科大学老龄化健康管理科技创新团队建设项目(CXTD202103);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2019FE001(-013))。

摘　　要：目的了解云南省安宁市围绝经期女性代谢综合征(metabolic syndrome,MS)的患病情况及其与高尿酸血症(hyperuricemia,HUA)的关系。方法该调查为现况调查,2021年5月采用问卷调查与体格检查相结合的方式收集多阶段分层抽样的45~60岁6721名围绝经期女性的人口学基本资料和临床资料[民族、所住社区、身高、体重、腰围、血压、空腹血糖、三酰甘油(TG)、血尿酸、高密度脂蛋白胆固醇(HDL-C)、丙氨酸氨基转移酶(ALT)等]。结果该研究6721名围绝经期女性的MS患病率为14.05%(95%CI 13.22%~14.88%),HUA患病率为6.46%(95%CI 5.88%~7.07%)。与围绝经期非HUA人群比,围绝经期HUA人群的年龄、HDL-C、尿素、直接胆红素、白蛋白的平均水平较低,TG、ALT、心率、体重指数(BMI)、肌酐水平较高(均P<0.05)。少数民族和有慢性病家族史的围绝经期女性人群HUA患病率高于汉族和无慢性病家族史者。围绝经期女性MS患病率随血尿酸升高而增加(Z=-15.3138,P<0.001)。多因素logistic回归模型显示,控制BMI、民族等协变量后,HUA与MS呈正相关(OR=1.526,95%CI 1.192~1.954),HUA组围绝经期女性患MS是非高尿酸组的1.526倍。结论HUA与围绝经期女性MS呈高度正相关,应加强对围绝经期女性尿酸水平的管理。Objective To assess the prevalence of metabolic syndrome(MS)and its relationship with hyperuricemia(HUA)in perimenopausal women in Anning city,Yunnan province.Methods This is a cross-sectional survey.In May 2021,a multi-stage stratified sampling method was used to collect demographics and clinical data[ethnicity,living community,height,weight,waist circumference,blood pressure,fasting plasma glucose,triglycerides(TG),serum uric acid,high density lipoprotein-cholesterol(HDL-C),alanine transaminase(ALT),etc]in a total of 6721 perimenopausal women aged 45-60 years.Results A total of 6721 perimenopausal women were included in this study.The prevalences of MS and HUA were 14.05%(95%CI 13.22%-14.88%)and 6.46%(95%CI 5.88%-7.07%),respectively.The average age,HDL-C,urea,direct bilirubin,and albumin levels in the perimenstrual HUA population were lower than those in the non-HUA population while the levels of TG,ALT,heart rate,body mass index(BMI),and creatinine were higher(all P<0.05).The prevalence of HUA in perimenopausal women with ethnic minorities and family history of chronic diseases was higher than that in Han nationality and without family history of chronic diseases.The prevalence of MS in perimenopausal women was increased with the increase of serum uric acid(Z=-15.3138,P<0.001).Multivariate logistic regression model showed that HUA was positively correlated with MS(OR=1.526,95%CI 1.192-1.954)after adjusting for covariates such as BMI and ethnicity,and the incidence of MS in perimenopausal women in HUA group was 1.526 folds higher than that in non-hyperuricemia group.Conclusion HUA is highly positively correlated with MS in perimenopausal women.The management of uric acid level in perimenopausal women should be strengthened.

关 键 词：代谢综合征 围绝经期 高尿酸血症 多因素模型 

分 类 号：R589[医药卫生—内分泌] R711.75[医药卫生—内科学]