P-选择素糖蛋白配体1在HIV感染过程中的作用  

The research of roles of P-selectin glycoprotein ligand-1 in HIV infection

作　　者：郭蕊 陈叶苗[1] 陈耀凯 申蕊[1,2] 鲁雁秋 崔红娟 唐圣权 严晓峰[1] GUO Rui;CHEN Yemiao;CHEN Yaokai;SHEN Rui;LU Yanqiu;CUI Hongjuan;TANG Shengquan;YAN Xiaofeng(Chongqing Public Health Medical Center,Chongging 400036,China;Southwest University,Medical Research Institute,Chongging 400715)

机构地区：[1]重庆市公共卫生医疗救治中心,重庆400036 [2]西南大学医学研究院,重庆400715

出　　处：《中国艾滋病性病》2023年第4期468-471,共4页Chinese Journal of Aids & STD

基　　金：重庆市首批公共卫生重点学科(专科)建设项目;重庆市科技局英才项目(cstc2021ycjh-bgzxm0275);重庆市技术创新与应用发展专项(cstc2020jscx-cylhX0001)。

摘　　要：P-选择素糖蛋白配体1(P-selectin glycoprotein ligand 1,PSGL-1)是存在于T淋巴细胞等细胞表面的一种跨膜糖蛋白,具有多种生物学活性,不仅参与炎症的形成与发展,参与肿瘤细胞的生长与转移,还具有广泛的抗微生物活性。近年,研究发现PSGL-1对HIV感染具有抑制作用,是HIV的限制性因子,也是潜在的HIV治疗新靶点。本文对PSGL-1及其生物学作用,以及PSGL-1在HIV感染过程中表达、抑制作用与机制进行了综述。P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein that exists on the surface of T lymphocytes and other cells and has a variety of biological activities. PSGL-1 is involved in not only the formation and development of inflammation but also the growth and metastasis of tumor cells. In recent years, PSGL-1 has been found to have an inhibitory effect on HIV infection, acting as a restriction factor for HIV replication. Studies also indicate that PSGL-1 could be a potential new target for HIV treatment in the future. In this article, we aimed to review the biological roles and cellular expression of PSGL-1, as well as PSGL-1's inhibitory effects on HIV infection and associated mechanisms.

关 键 词：P-选择素糖蛋白配体1 艾滋病病毒 感染 

分 类 号：R512.91[医药卫生—内科学]