卡瑞利珠单抗所致不良反应的文献病例分析  

Case analysis of literature on adverse drug reactions induced by Camrelizumab

作　　者：李君霞[1] 陈爽[1] 赵丽玲 谢若函 LI Junxia;CHEN Shuang;ZHAO Liling;XIE Ruohan(Department of Pharmacy,Henan Provincial Chest Hospital,Zhengzhou 450008,China)

机构地区：[1]河南省胸科医院药学部,河南郑州450008

出　　处：《肿瘤基础与临床》2023年第2期127-132,共6页journal of basic and clinical oncology

摘　　要：目的 分析卡瑞利珠单抗所致不良反应发生情况、严重程度、累及器官及各种可能出现的不良反应的临床特点,为临床安全合理用药及患者用药监护提供参考。方法 以“卡瑞利珠单抗”或“卡瑞丽珠单抗”或“SHR-1210”或“camrelizumab”为主题词,检索中国知网数据库、万方数据库、维普数据库及PubMed关于卡瑞利珠单抗的个案报道,并将相关不良反应汇总分析。结果 本次检索发现关于卡瑞利珠单抗的不良反应个案报道共计15例,其中男12例、女3例,年龄40~85岁,其中50~70岁较多(12例,80.00%)。主要累及系统有皮肤、呼吸系统、内分泌系统、消化系统、血液系统,其中累及皮肤、黏膜的反应性毛细血管增生症发生比例最高,其次为内分泌相关的甲状腺功能异常发生比例。结论 卡瑞利珠单抗的真实世界应用中可能有比报道更高比例的反应性毛细血管增生症和其他免疫相关不良事件的发生,随着其临床应用范围的不断扩大,其他发生比例相对较低的不良反应或新的不良反应或将出现,临床医师与药师亟需提高对其相关不良反应的敏感性,并提供对症支持措施,保障患者用药安全。Objective To analyze the incidence,severity,organ involvement and various possible clinical characteristics of adverse reactions caused by camrelizumab,and to provide references for rational drug use and necessary medication monitoring.Methods The CNKI,Wanfang database,VIP database and PubMed were retrieved with the subject headings of "camrelizumab" or "SHR-1210",and the collected literatures were analyzed statistically.Results A total of 15 patients with adverse reactions related to camrelizumab were reported in this search,included 12 male patients and 3 female patients,the age was 40-85 years,the main age range was 50-70 years(12 patients,80.00%).The main involved system were skin,respiratory system,endocrine system,digestive system and blood system.Among them,reactive cutaneous capillary endothelial proliferation was the highest incidence,followed by endocrine-related thyroid dysfunction.Conclusion In the real-world application of carrelizumab,there may be a higher proportion of reactive cutaneous capillary endothelial proliferation and other immune-related adverse events than reported.With the continuous expansion of its clinical application,low adverse reactions or new adverse reactions may appear.Clinicians and pharmacists urgently need to improve their sensitivity to related adverse reactions and provide symptomatic support measures to ensure the safety of patients.

关 键 词：卡瑞利珠单抗 免疫 不良反应 

分 类 号：R979.1[医药卫生—药品]