136例2型糖尿病患者肌肉痉挛的发生频率及危险因素  

Frequency and risk factors of muscle cramp in 136 cases of type 2 diabetes mellitus

作　　者：李金泉 高美芳 闫飞[1] 董明[1] LI Jinquan;GAO Meifang;YAN Fei;DONG Ming(Department of Endocrinology,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China)

机构地区：[1]山东大学齐鲁医院内分泌科,山东济南250012

出　　处：《山东大学学报（医学版）》2023年第5期20-24,共5页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金(ZR2022MH182)。

摘　　要：目的 探讨2型糖尿病(T2DM)患者发生肌肉痉挛的频率及危险因素。方法 选取2021年7月至9月于山东大学齐鲁医院内分泌科住院的136例T2DM患者为研究对象,根据肌肉痉挛量表评估的结果,分为肌肉痉挛组(n=65)、无肌肉痉挛组(n=71)。收集两组患者年龄、性别、吸烟饮酒史、体质量指数(BMI)、平均动脉压(MAP)、糖尿病病程、血糖、糖化血红蛋白(HbA1c)、空腹C肽,以及血清肌酐(Scr)、白蛋白(ALB)、总钙(Ca)、镁(Mg)、维生素D(VIT-D)水平等一般情况和临床资料。应用多因素二分类Logistic回归分析影响T2DM患者合并肌肉痉挛的危险因素。结果 47.8%(65/136)患者存在不同程度的肌肉痉挛,其血白蛋白水平显著低于无肌肉痉挛患者(P=0.023),糖尿病病程亦明显延长(P=0.045);两组年龄、性别、吸烟率、饮酒率、BMI、MAP及血糖、HbA1c、空腹C肽、Scr、Ca、Mg、VIT-D水平差异无统计学意义(P均>0.05)。多因素Logistic回归分析显示,糖尿病病程长(OR=1.068,95%CI:1.008~1.131)和低血白蛋白水平(OR=1.159,95%CI:1.015~1.323)为T2DM肌肉痉挛的独立危险因素。结论 长糖尿病病程和低血白蛋白水平可能是T2DM患者发生肌肉痉挛的独立危险因素。Objective To investigate the frequency of muscle cramp and analyze the risk factors in patients with type 2 diabetes mellitus(T2DM).Methods A total of 136 T2DM patients were involved and assessed with the Muscle Spasm Scale.According to the results of the scale,they were divided into muscle cramp group(n=65)and non muscle cramp group(n=71).Patients'age,gender,body mass index(BMI),smoking history,alcohol consumption,mean arterial pressure(MAP),duration of diabetes,plasma glucose,glycosylated hemoglobin A1c(HbA1c),fasting C-peptide,serum albumin(ALB),serum creatinine(Scr),magnesium(Mg),total calcium(Ca)and vitamin D(VIT-D)were assessed.Risk factors of muscle cramp were screened with multivariate binary Logistic regression.Results The study revealed that 47.8%(65/136)patients suffered from various degrees of muscle cramp.The ALB level of the muscle cramp group was significantly lower than that of the non muscle spasm group(P=0.023).The dura-tion of diabetes was also significantly prolonged(P=0.045).There were no significant differences in other parameters between the two groups(P>0.05).Multivariate Logistic regression showed that increased duration of diabetes(OR=1.068,95%CI:1.008-1.131)and reduced ALB level(OR=1.159,95%CI:1.015-1.323)were independent risk fac-tors of muscle cramp.Conclusion Decreased ALB level and extended diabetes duration may be independent risk fac-tors for the occurrence of muscle cramp in patients with T2DM.

关 键 词：2型糖尿病 肌肉痉挛 糖尿病病程 白蛋白 

分 类 号：R587.1[医药卫生—内分泌]