光热疗法中热休克蛋白的抑制策略及其研究进展  

Research Progress on Inhibitory Strategies of Heat Shock Proteins in Photothermal Therapy

作　　者：蒙艺灵 温涛 许海燕[1] Meng Yiling;Wen Tao;Xu Haiyan(Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005,China)

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础学院,北京100005

出　　处：《中国生物医学工程学报》2023年第2期229-234,共6页Chinese Journal of Biomedical Engineering

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-026)

摘　　要：光热疗法是在外部光源照射下利用光热剂精准高效杀死肿瘤细胞的疗法,其在实体瘤治疗领域具有广阔的应用前景。然而,近年来研究发现,光热疗法会导致细胞热休克蛋白的异常上调,使细胞的耐热性能增强而影响治疗效果。为了克服热休克蛋白对光热治疗效果的影响,近年来提出了多种解决策略。对光热疗法中依据不同原理采取的热休克蛋白抑制策略及研究进展进行分类,通过主要的典型研究实例进行介绍,包括:在光热治疗体系中加入热休克蛋白抑制剂、阻断肿瘤细胞的糖酵解代谢、诱导产生脂质过氧化物或高活性氧以及对热休克蛋白基因进行干扰和基因敲除等,并对不同策略的优缺点进行比较和总结。最后,对光热治疗系统中热休克蛋白抑制策略的未来发展进行展望,指出使用多方法联合,或设计新型载体和药物是克服现有策略局限性的重要途径。Photothermal therapy(PTT)can kill tumor cells accurately and efficiently by using photothermal agents under the irradiation of external light source,so it has a broad application prospect in the treatment of solid tumors.However,recent studies have observed that PTT may lead to abnormal upregulation of heat shock proteins(HSPs)in the cells,which enhances the heat resistance of cells and affects the therapeutic effect.Aiming to overcome the adverse influence of HSPs on the efficiency of photothermal treatment,various strategies have been developed in recent years.In this paper,inhibitory strategies for HSPs in PTT were classified according to the different principles,and the corresponding research progresses were introduced through study cases.The strategies mainly include the application of HSPs inhibitors in PTT system,blocking the glycolysis metabolism of tumor cells,inducing the production of lipid peroxide or highly reactive oxygen species(ROS),and HSPs gene interference and gene knockout.In addition,the advantages and limitations of the various strategies were compared and summarized.At the end,perspectives of HSP inhibition in photothermal therapy systems were discussed,and we proposed that joint strategies or designing new carriers and drugs would be promising to overcome the limitations of existing strategies.

关 键 词：光热疗法 热休克蛋白 抑制 

分 类 号：R318[医药卫生—生物医学工程]