溃结灵灌肠联合红光治疗肛隐窝炎临床研究  

Clinical Study of Kuijieling Enema Combined with Red Light in the Treatment of Anal Cryptitis

作　　者：张志刚 孔赛[2] 王漠烟 马先陆 ZHANG Zhigang;KONG Sai;WANG Moyan;MA Xianlu(Huangshi Traditional Chinese Medicine Hospital of Eastern Hubei Medical Group,Huangshi,Hubei,China 435001;Huangshi Central Hospital of Eastern Hubei Medical Group,Huangshi,Hubei,China 435099;People's Hospital of Daye City,Huangshi,Hubei,China 435199)

机构地区：[1]鄂东医疗集团黄石市中医医院,湖北黄石435001 [2]鄂东医疗集团黄石市中心医院,湖北黄石435099 [3]湖北省大冶市人民医院,湖北黄石435199

出　　处：《中国药业》2023年第11期89-92,共4页China Pharmaceuticals

基　　金：湖北省黄石市医疗卫生科技计划项目[2019A29]。

摘　　要：目的探讨溃结灵灌肠联合红光治疗肛隐窝炎的临床疗效,以及对患者血清白细胞介素6(IL-6)、P物质(SP)、5-羟色胺(5-HT)水平的影响。方法选取鄂东医疗集团黄石市中医医院2020年10月至2021年5月收治的肛隐窝炎患者80例,按随机数字表法分为观察组和对照组,各40例。观察组患者予溃结灵灌肠联合红光治疗,对照组患者予常规西药灌肠治疗,均治疗10 d。结果观察组总有效率为97.50%,显著高于对照组的87.50%(P<0.05);治疗后,两组患者中医症状体征(肛门灼痛、肛门坠胀、肛门潮湿、肛门镜检)积分及血清炎性因子白细胞介素6(IL-6)、P物质(SP)、5-羟色胺(5-HT)表达水平均显著降低,且观察组均显著低于对照组(P<0.05);观察组和对照组治疗期间不良反应发生率相当(2.50%比7.50%,P>0.05)。结论溃结灵灌肠联合红光治疗肛隐窝炎的临床疗效良好,可减轻患者的肛周不适,降低炎性因子水平,且安全性良好。Objective To investigate the clinical efficacy of Kuijieling enema combined with red light in the treatment of anal cryptitis,and its effect on serum levels of interleukin-6(IL-6),substance P(SP),and 5-hydroxytryptamine(5-HT).Methods A total of 80 patients with anal cryptitis admitted to the Huangshi Traditional Chinese Medicine Hospital of Eastern Hubei Medical Group from October 2020 to May 2021 were selected and divided into the observation group and the control group by the random number table method,with 40 cases in each group.The patients in the observation group were treated with Kuijieling enema combined with red light therapy,while the patients in the control group were treated with conventional Western medicine enema.Both groups were treated for 10 d.Results The total effective rate in the observation group was 97.50%,which was significantly higher than 87.50%in the control group(P<0.05).After treatment,the scores of traditional Chinese medicine symptoms and signs(burning pain,bloating,dampness,and colonoscopy)and the expression levels of serum inflammatory factors sunch as interleukin-6(IL-6),Substance P(SP),and 5-hydroxytryptamine(5-HT)in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than those in the control group(P<0.05).During treatment,the incidence of adverse reactions in the observation group was comparable to that in the control group(2.50%vs.7.50%,P>0.05).Conclusion Kuijieling enema combined with red light is effective and safe in the treatment of anal cryptitis,which can alleviate perianal discomfort symptoms,and reduce inflammatory factor levels.

关 键 词：溃结灵 红光 肛隐窝炎 临床疗效 炎性因子 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]