南宁市性病门诊就诊者直肠淋球菌感染的流行病学研究  

Epidemiological study on rectal Neisseria gonorrhoeae infection among attendees at a sexually transmitted disease clinic in Nanning

作　　者：朱邦勇 韩燕 甘泉 尹跃平 陈媚 陈凯 郭春平 施美琴 韦江平 黄寅杰 蒙琳 Zhu Bangyong;Han Yan;Gan Quan;Yin Yueping;Chen Mei;Chen Kai;Guo Chunping;Shi Meiqin;Wei Jiangping;Huang Yinjie;Meng Lin(Institute of Dermatology,Guangxi Autonomous Region,Nanning 530003,China;Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]广西壮族自治区皮肤病防治研究所中心实验室,南宁530003 [2]中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所),性病参比实验室,南京210042

出　　处：《国际流行病学传染病学杂志》2023年第2期127-131,共5页International Journal of Epidemiology and Infectious Disease

基　　金：中国公共卫生联盟项目(GWLM202004);广西皮肤性病科临床重点专科建设项目(桂卫医发【2019】44号);中国医学科学院医学与健康科技创新工程项目(2021-I2M-C&T-B-086)。

摘　　要：目的了解广西南宁性病门诊就诊者直肠淋球菌感染的流行状况及其危险因素。方法收集并分析广西壮族自治区皮肤病医院2018年7月至2020年9月性病门诊就诊者的直肠淋球菌感染情况,采用多因素Logistic回归法分析感染的相关危险因素。结果共纳入829例性病门诊患者的相关信息,但其中7例患者的泌尿生殖道样本和4例患者的直肠样本检测失败。其余样本中直肠淋球菌感染率为2.1%(17/825,95%CI:1.2%~3.4%),泌尿生殖道淋球菌感染率为6.4%(53/822,95%CI:4.9%~8.4%);男性患者和女性患者直肠淋球菌感染率分别为1.3%(5/395,95%CI:0.5%~3.1%)和2.8%(12/430,95%CI:1.5%~5.0%)。多因素Logistic回归分析显示:30岁以下(aOR=8.664,95%CI:1.426~52.652)、直肠感染沙眼衣原体(aOR=21.505,95%CI:3.452~133.978)及泌尿生殖道感染淋球菌(aOR=114.499,95%CI:20.380~643.279)是直肠感染淋球菌的高风险因素。结论南宁市性病门诊患者中直肠淋球菌感染率相对较低。30岁以下、泌尿生殖道感染淋球菌及直肠感染沙眼衣原体是就诊者直肠感染淋球菌的危险因素。Objective To explore the prevalence and potential risk factors of rectal Neisseria gonorrhoeae(NG)infection among attendees at the sexually transmitted disease(STD)clinic in Nanning,Guangxi.Methods Data of rectal NG infection among STD clinic attendees in Dermatology Hospital of Guangxi Zhuang Autonomous Region from July 2018 to September 2019 were collected and analyzed.Multiple Logistic regression analysis was conducted to explore the risk factors for rectal NG infection.Results There were 829 outpatients enrolled,among whom 7 urogenital and 4 rectal specimens were failed for PCR amplification experiment.The positive rates of NG in rectal and urogenital samples were 2.1%(17/825,95%CI:1.2%-3.4%)and 6.4%(53/822,95%CI:4.9%-8.4%),respectively.The positive rates of NG in males and females were 1.3%(5/395,95%CI:0.5%-3.1%)and 2.8%(12/430,95%CI:1.5%-5.0%),respectively.Multiple Logistic regression analysis showed that patients under 30(aOR=8.664,95%CI:1.426-52.652),infection with rectal Chlamydia trachomatis(aOR=21.505,95%CI:3.452-133.978)and infection with urogenital NG(aOR=114.499,95%CI:20.380-643.279)were high-risk factors for rectal NG infection.Conclusions The prevalence of rectal NG among STD clinic attendees in Nanning is relatively low.Attendees under 30 years old,with urogenital NG and rectal Chlamydia trachomatis infection are at risk for rectal NG infection.

关 键 词：奈瑟球菌 淋病 直肠 性病门诊就诊者 流行病 危险因素 

分 类 号：R759.2[医药卫生—皮肤病学与性病学] R181.3[医药卫生—临床医学]