多环芳烃相关代谢酶CYP1A1和GSTP1基因多态性与不良孕产史的关系  

Correlation between polycyclic aromatic hydrocarbon-related metabolic enzymes CYP1A1 and GSTP1 gene polymorphisms with the adverse pregnancy history

作　　者：陈立霞 李燕 岳婷 史建林 宋瑶 刘璇 李淑荣 CHEN Lixia;LI Yan;YUE Ting(Department of Family Planning,Zhangjiakou Maternal and Child Health Hospital,Hebei,Zhangjiakou 075000,China)

机构地区：[1]河北省张家口市妇幼保健院计划生育科,075000

出　　处：《河北医药》2023年第8期1218-1221,共4页Hebei Medical Journal

摘　　要：目的分析多环芳烃细胞色素P4501A1(CYP1A1)、谷胱肽转移酶P1(GSTP1)代谢酶基因多态性与不良孕产史的关联。方法回顾性研究2018年1月至2020年1月接诊的618例有不良孕产史的孕产妇,将其设为作为研究组,选定同期600例健康孕妇作为健康组,对比2组CYP1A1、GSTP1基因多态性,对比2组孕前体质量指数(BMI)、不良孕产史次数、是否服用叶酸、是否存在有害因素接触史、有无妊高症、妊娠糖尿病,Logistic回归分析不良孕产史传统影响因素与CYP1A1、GSTP1基因多态性的关系。结果CYP1A1 MspI基因型GG比例研究组(80.26%)高于健康组(54.50%),CYP1A1 MspI基因频率分布2组比较,差异有统计学意义(P<0.05,95%CI:0.738~0.938)。研究组GSTP1 SnaBI基因型GG比例(52.43%)高于健康组(44.33%),2组GSTP1 MspI基因频率分布对比,差异有统计学意义(P<0.05,95%CI:0.744~0.928)。Logistic回归分析不良孕产史的独立危险因素是CYP1A1、GSTP1基因多态性(P<0.05),以无序多分类反应变量分析,孕前BMI、不良孕产史次数、叶酸服用史、有害因素接触史与CYP1A1、GSTP1基因多态性无相关性(P>0.05),CYP1A1、GSTP1基因多态性会增加妊娠期高血压综合征、妊娠糖尿病发生风险,差异有统计学意义(P<0.05)。结论CYP1A1、GSTP1基因多态性是不良孕产史的易感因素,也是妊高症、妊娠糖尿病的危险因素。Objective To analyze the correlation between polycyclic aromatic hydrocarbon-related metabolic enzymes cytochrome P4501A1(CYP1A1)and Glutathione S-transferase P1(GSTP1)and gene polymorphisms with the adverse pregnancy history.Methods It was a retrospective study involving 618 pregnant women with a adverse pregnancy history in our hospital from January 2018 to January 2020,which were enrolled in the research group.During the same period,600 healthy pregnant women were enrolled in the healthy group.CYP1A1 and GSTP1 gene polymorphisms,pre-pregnancy body mass index(BMI),the number of adverse pregnancy history,use of folic acid,history of exposure to harmful factors,pregnancy-induced hypertension and gestational diabetes were compared between the two groups.Logistic regression analysis was performed to identify the correlation between traditional influencing factors for adverse pregnancy history with CYP1A1 and GSTP1 gene polymorphisms.Results The proportions of the GG genotype of CYP1A1 MspI(80.26%vs 54.50%,95%CI:0.738-0.938,P<0.05)and GG genotype of GSTP1 SnaBI(52.43%vs 44.33%,95%CI:0.744-0.928,P<0.05)in the research group were significantly higher than those of healthy group.Logistic regression analysis showed that CYP1A1 and GSTP1 gene polymorphisms were the independent risk factors for the adverse pregnancy history(P<0.05).Multinomial logistic regression analysis showed that pre-pregnancy BMI,number of adverse pregnancy history,use of folic acid,and history of exposure to harmful factors were not correlated with CYP1A1 and GSTP1 gene polymorphisms(P>0.05).CYP1A1 and GSTP1 gene polymorphisms significantly increased the risks of pregnancy-induced hypertension and gestational diabetes(P<0.05).Conclusion CYP1A1 and GSTP1 gene polymorphisms are susceptibility factors for adverse pregnancy history,which are also risk factors for pregnancy-induced hypertension and gestational diabetes.

关 键 词：细胞色素P4501A1 谷胱甘肽转移酶P1 基因多态性 不良孕产史 

分 类 号：R714.2[医药卫生—妇产科学]