Ang-2、IL-6在子宫肌瘤患者中的表达及其与术后转归的相关性  

Expression of Ang-2 and IL-6 in Patients with Hysteromyoma and Their Correlation with Postoperative Outcome

作　　者：邓正凤 吕琳 曾德春 范婷婷[1] DENG Zhengfeng;LV Lin;ZENG Dechun(Department of Gynecology,Hechuan District People’s Hospital,Chongqing City 401520)

机构地区：[1]重庆市合川区人民医院妇科,401520

出　　处：《医学理论与实践》2023年第11期1820-1823,共4页The Journal of Medical Theory and Practice

摘　　要：目的:观察子宫肌瘤患者组织中促血管生成素(Ang)-2、白细胞介素(IL)-6的表达情况,并分析其与子宫肌瘤剔除术后转归的关系。方法:选取2018年6月—2019年6月在我院接受腹腔镜子宫肌瘤剔除术治疗的106例子宫肌瘤患者作为研究对象,所有患者术后接受为期3年随访,随访期间,根据肌瘤复发情况评估患者病情转归情况,分为复发组和未复发组。术前采集患者空腹静脉血,检测性激素水平[孕酮(P)、卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]、术中将所切取肌瘤标本送检,检测组织中Ang-2、IL-6表达,采用Logistics回归分析各指标与子宫肌瘤术后转归的关系。结果:随访期间总复发率为28.30%,未复发占71.70%;复发组肌瘤直径长于未复发组,组织中Ang-2、IL-6表达高于未复发组,血清P、FSH、E_(2)、LH表达高于未复发组差异有统计学意义(P<0.05);经Logistic回归分析显示,组织中Ang-2、IL-6过表达,血清P、LH过表达与子宫肌瘤术后复发有关(P<0.05);绘制受试者工作特征(ROC)曲线图显示,组织中Ang-2、IL-6预测子宫肌瘤术后复发的曲线下面积(AUC)分别为0.795、0.803,均有一定预测效能。绘制决策曲线显示,在阈值0.2~0.4范围内,组织中Ang-2、IL-6联合预测子宫肌瘤术后复发的净获益率高于单一检测。结论:子宫肌瘤组织Ang-2、IL-6过表达与术后肌瘤复发有关,检测Ang-2、IL-6表达量可预测术后肌瘤复发风险。Objective:To observe the expression of angiopoietin(ANG)-2 and interleukin(IL)-6 in tissues of patients with hysteromyoma,and to analyze their relationship with postoperative outcome of hysteromyoma.Methods:106 patients with hysteromyoma who received laparoscopic myomectomy in our hospital from June 2018 to June 2019 were selected as the study subjects.All patients were followed up for 3 years after operation.According to the recurrence of myoma during follow-up,the disease outcomes of patients were evaluated.Divided them into recurrence group and non recurrence group.The levels of sex hormones[progesterone(P),follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)]of patients were measured before operation.The myoma specimens were sent for examination during operation,the expressions of Ang-2 and IL-6 in tissues were detected.The relationship between each index and postoperative outcome of hysteromyoma was analyzed by Logistics regression.Results:The total recurrence rate was 28.30%,and no recurrence accounted for 71.70%during follow-up;compared with non recurrence group,the diameter of leiomyoma was longer,the expressions of Ang-2 and IL-6 in tissues were higher,and the expressions of serum P,FSH,E_(2) and LH were higher in recurrence group,the difference was statistically significant(P<0.05);Logistic regression analysis showed that,the overexpression of Ang-2 and IL-6 in tissues and the overexpression of serum P and LH were related to the recurrence of hysteromyoma after operation(P<0.05),the receiver operating characteristic(ROC)curve was drawn and showed that,the area under the curve(AUC)of Ang-2 and IL-6 in tissues for predicting postoperative recurrence of hysteromyoma were 0.795 and 0.803 respectively,which had certain predictive efficiency.Conclusion:The overexpression of Ang-2 and IL-6 in tissues of hysteromyoma is related to postoperative recurrence of myoma.Detecting the expression of Ang-2 and IL-6 can predict the risk of postoperative leiomyoma recurrence.

关 键 词：子宫肌瘤 腹腔镜子宫肌瘤剔除术 复发 促血管生成素-2 白细胞介素-6 性激素 

分 类 号：R711.76[医药卫生—妇产科学]