基于太赫兹超表面传感器的硝基呋喃类药物痕量检测  

Trace Detection of Nitrofuran Drugs Based on Terahertz Meta-Surface Sensor

作　　者：袁婷婷 吴靖文 薄艳华 刘建军[1] 洪治[1] 杜勇[1] Yuan Tingting;Wu Jingwen;Bo Yanhua;Liu Jianjun;Hong Zhi;Du Yong(Center for Terahertz Research,China Jiliang University,Hangzhou 310018,Zhejiang,China)

机构地区：[1]中国计量大学太赫兹技术与应用研究所,浙江杭州310018

出　　处：《光学学报》2023年第7期163-171,共9页Acta Optica Sinica

基　　金：国家自然科学基金(62275238,61875179);浙江省自然科学基金(LY19B050003)。

摘　　要：硝基呋喃是一种广谱抗生素,其衍生物应用广泛;但摄入过量,会发生溶血性贫血、急性肝坏死等疾病。传统检测方法样品用量大、检测时间长且过程复杂;超表面传感器检测方法样品用量小且检测快速、简单方便。提出一种基于对称开口环的太赫兹超表面微结构器件,该结构折射率灵敏度达到196 GHz/RIU,可应用于高灵敏度传感检测。利用该超表面传感器对两种不同质量浓度的呋喃唑酮和呋喃妥因溶液进行痕量实验检测,结果表明,该超表面传感器对两种药物的最低检测质量浓度达到10 mg/dL,有望应用于生物医学等领域样品的传感检测。Objective Nitrofuran is a typical broad-spectrum antibiotic.Its derivatives and nitrofuran compounds are widely used in clinical practice and veterinary medicine and can be employed to preserve animal feed,prevent and treat gastrointestinal infections caused by bacteria,and accelerate animal growth.However,studies have proven that nitrofuran and its metabolites have carcinogenic and teratogenic side effects on humans and that diseases such as hemolytic anemia and acute liver necrosis can also occur if excess nitrofuran antibiotics are consumed.This has gradually caused concern.Therefore,high-sensitivity monitoring of nitrofuran is important for safeguarding human health and life safety.Traditional methods such as chromatography,enzyme-linked immunosorbent assay(ELISA),and liquid chromatography-mass spectrometry(LC-MS)have the disadvantages of a long pre-treatment and analysis period,cumbersome processing,massive sample usage,and a high false-positive rate of test results.Therefore,it is necessary to find a rapid,accurate,and stable assay for monitoring the use of nitrofuran drugs.As biological samples are often present in a diluted state,sensitive detection of biomolecules without any binding site markers or aids remains challenging.Metamaterials have unique optical properties and exhibit unique characteristics,such as local electric field enhancement,which can be tuned by the geometric design of metamaterials.The electric field enhancement in metamaterials can improve the interaction between the sample and terahertz(THz)waves.Thus,the use of THz metamaterials as a sensing platform can overcome the low sensitivity of biological samples in the THz range and enable biomolecular detection in a label-free manner.We hope that the use of metamaterials will enable the non-destructive and rapid detection of nitrofuran drugs.Methods THz waves are parts of electromagnetic waves between far infrared and microwave,which have good safety and fingerprinting properties for substance identification without damaging effects on su

关 键 词：生物技术 太赫兹 超表面 呋喃类药物 高灵敏度传感 痕量检测 

分 类 号：O433[机械工程—光学工程]