维持性血液透析患者皮肤瘙痒临床研究进展  

Clinical research progress of pruritus in patients undergoing maintenance hemodialysis

作　　者：邱瑛[1] 杨玉洁[1] 袁怀红[1] QIU Ying;YANG Yujie;YUAN Huaihong(Hemodialysis Center,Department of Nephrology,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院肾脏内科血液透析中心,四川成都610041

出　　处：《陕西医学杂志》2023年第6期775-776,F0003,共3页Shaanxi Medical Journal

基　　金：四川省卫生和计划生育委员会科研课题(18PJ363)。

摘　　要：皮肤瘙痒是维持性血液透析(MHD)患者的常见合并症,其发生与发展涉及一系列复杂的生理病理变化,发病机制尚未阐明,目前发现与皮肤含水量、尿毒症毒素蓄积、离子代谢紊乱、内分泌失调、微炎症状态、免疫功能紊乱、组胺水平异常、周围神经病变等多因素有关。基于多种发病机制也衍生出多样化的治疗方案,如血液透析联合血液灌流、高通量血液透析、抗过敏治疗等。现对目前MHD患者皮肤瘙痒发病机制和治疗方案的研究进展进行阐述。Pruritus is a common complication in patients undergoing maintenance hemodialysis(MHD).Its occurrence and development involve a series of complex physiological and pathological changes.The pathogenesis of pruritus has not been elucidated.At present,it is found to be related to skin water content,uremic toxin accumulation,ion metabolism disorder,endocrine disorder,micro-inflammatory state,immune dysfunction,abnormal histamine level,peripheral neuropathy and other factors.A variety of treatments have also been derived based on a variety of pathogenesis,such as hemodialysis combined with hemoperfusion,high-flux hemodialysis,anti-allergic therapy,etc.This article reviews the current research progress on the pathogenesis and treatment of pruritus in MHD patients.

关 键 词：维持性血液透析 皮肤瘙痒 发病机制 毒素蓄积 微炎症状态 高通量血液透析 

分 类 号：R275.9[医药卫生—中西医结合]