基于功能MR评估轻重度吸烟成瘾患者动态功能连接密度的差异  

Differences in dynamic functional connectivity density in individuals with light and heavy smoking addiction: a study based on functional MR

作　　者：牛晓玉 张勇[1] 杨镇圭 张孟哲 高昕宇 汪卫建 程敬亮[1] Niu Xiaoyu;Zhang Yong;Yang Zhengui;Zhang Mengzhe;Gao Xinyu;Wang Weijian;Cheng Jingliang(Department of MRI,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450002

出　　处：《中华放射学杂志》2023年第5期490-497,共8页Chinese Journal of Radiology

基　　金：国家重点研发计划项目(SQ2018YFC130095);河南省科技攻关项目(172102310391);河南省重点研发与推广专项(科技攻关)支持项目(212102310712)。

摘　　要：目的基于功能MR探讨吸烟成瘾患者动态功能连接密度(dFCD)改变的脑区及其与尼古丁依赖量表(FTND)评分的关系。方法回顾性分析2019年9月至2020年12月通过微信等网络平台在郑州大学第一附属医院招募的176名志愿者的临床及影像资料。均为男性,年龄20~55岁,根据文献结果分为吸烟成瘾轻度组(59例)、吸烟成瘾重度组(61例)、对照组(56例)。所有受试者均接受静息态功能MR扫描并计算dFCD。采用方差分析对3组dFCD进行分析(GRF校正,体素水平P<0.005,团块水平P<0.01),两两比较采用Bonferroni校正。采用Pearson偏相关分析差异有统计学意义脑区dFCD与FTND的相关性。结果吸烟成瘾轻度组、吸烟成瘾重度组及对照组dFCD差异脑区主要分布在右侧眶额皮层、左侧尾状核、右侧壳核、双侧距状裂周围皮层、右侧楔叶、左侧海马旁回、左侧楔前叶、左侧颞中回和双侧丘脑(GRF校正,体素水平P<0.005,团块水平P<0.01)。吸烟成瘾轻度组和吸烟成瘾重度组相较于对照组均表现出双侧距状裂周围皮层、右侧楔叶、左侧楔前叶的dFCD降低,右侧眶额皮层、右侧壳核、左侧尾状核及左侧丘脑的dFCD增加(Bonferroni校正,P<0.05)。吸烟成瘾重度组相较于对照组右侧丘脑dFCD增加;吸烟成瘾轻度组相较于对照组左侧颞中回dFCD降低(Bonferroni校正,P<0.001);吸烟成瘾重度组相较于吸烟成瘾轻度组左侧颞中回和右侧丘脑dFCD增加,左侧海马旁回dFCD降低(Bonferroni校正,P<0.05)。吸烟成瘾患者右侧丘脑dFCD值与FTND评分呈正相关(r=0.227,P=0.014),其中吸烟成瘾重度组右侧丘脑dFCD值与FTND评分呈正相关(r=0.323,P=0.013),吸烟成瘾轻度组与FTND评分无相关性(P>0.05)。结论不同程度吸烟成瘾者间存在与吸烟行为相关的脑区改变,并且重度吸烟成瘾人群的吸烟行为相较于轻度吸烟成瘾人群更趋向于习惯性。Objective To investigate the changes in dynamic functional connectivity density(dFCD)and its relationship with Fagerström test for nicotine dependence(FTND)scores in individuals with smoking addiction based on functional MR.Methods The clinical and imaging data of 176 volunteers recruited through wechat and other online platforms from September 2019 to December 2020 in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed.The 176 volunteers were male,aged 20 to 55 years old,and were divided into light smoking addiction group(59 cases),heavy smoking addiction group(61 cases)and control group(56 cases).All subjects underwent resting state functional MR scanning and dFCD was calculated.The dFCD values of three groups were analyzed by ANOVA analysis(GRF corrected,voxel level P<0.005,cluster level P<0.01).Bonferroni correction was used for pairwise comparison.Pearson partial correlation analysis was used to analyze the correlation between dFCD values of brain regions with statistically significant differences and FTND scores.Results Differences in dFCD among light smoking addiction group,heavy smoking addiction group and control group were mainly distributed in the right orbitofrontal cortex,left caudate nucleus,right putamen,bilateral calcarine sulcus cortex,right cuneus,left parahippocampal gyrus,left precuneus,left middle temporal gyrus and bilateral thalamus(GRF corrected,voxel level P<0.005,cluster level P<0.01).Compared with the control group,both the light and heavy smoking addiction groups showed decreased dFCD in the bilateral calcarine sulcus cortex,right cuneus and left precuneus,as well as increased dFCD in the right orbitofrontal cortex,right putamen,left caudate nucleus and left thalamus(Bonferroni corrected,P<0.05).Compared with the control group,the heavy smoking addiction group showed increased dFCD in the right thalamus,and the light smoking addiction group showed decreased dFCD in the left middle temporal gyrus(Bonferroni corrected,P<0.001).Compared with the light smok

关 键 词：行为 成瘾 吸烟 磁共振成像 动态功能连接密度 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.6[医药卫生—诊断学]