小而密低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与颈动脉内膜中层厚度的关系  

The Relationship Between the Ratio of Small Dense Low-Density Lipoprotein Cholesterol and High- Density Lipoprotein Cholesterol and Carotid Intima-Media Thickness

作　　者：马福存 柏明见[1] 王兵 梁国威[1] 李秀锋[1] MA Fucun;BAI Mingjian;WANG Bing;LIANG Guowei;LI Xiufeng(The Department of Clinical Laboratory Medicine,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院检验科,北京100049

出　　处：《标记免疫分析与临床》2023年第2期203-207,共5页Labeled Immunoassays and Clinical Medicine

基　　金：航天中心医院科研基金项目(编号:YN201914)。

摘　　要：目的 探讨小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein cholesterol, sdLDL-C)与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)的比值与颈动脉内膜中层厚度(carotid intima-media thickness, CIMT)的关系。方法 收集2016年3月至2017年3月航天中心医院体检人群1 350例数据,根据颈动脉B超结果分为两组:颈动脉内膜中层厚度正常组(CIMT<1mm)985例(男性508例,女性477例);颈动脉内膜中层厚度异常组(CIMT≥1mm)365例(男性273例,女性92例)。采用多元线性回归,Logistic回归和限制性立方样条回归模型评估sdLDL-C/HDL-C与颈动脉内膜中层厚度的关系。结果 随着sdLDL-C/HDL-C的增加,CIMT厚度也逐渐的增大;二元Logistic回归分析,sdLDL-C/HDL-C以Q1为参照,Q4经多变量调整后异常CIMT的OR=3.72(95%CI1.86~7.41)。限制性立方样条回归显示,sdLDL-C/HDL-C与异常CIMT(P<0.001)呈线性相关。此外,在正常LDL-C(low-density lipoprotein cholesterol, LDL-C)水平的亚样本人群中(n=991),sdLDL-C/HDL-C与CIMT相关性仍然显著。结论 在体检人群中,sdLDL-C/HDL-C升高与CIMT呈正相关,并且在正常LDL-C水平的人群中,两者依然呈正相关。sdLDL-C/HDL-C是预测颈动脉厚度较好的指标。Objective To investigate the relationship between the ratio of small dense low-density lipoprotein cholesterol and high-density lipoprotein cholesterol and carotid intima-media thickness.Methods From March,2016 to March,2017,1,350 people underwent physical examinations were enrolled in aerospace center hospital.According to the results of ultrasonography,these subjects were divided into two groups:985 patients(508 males and 477 females)with normal carotid intima-media thickness(CIMT<1mm)and 365 patients(273 males and 92 females)with abnormal carotid intima-media thickness(CIMT≥1mm).Multiple linear regression,logistic regression and restricted cubic spline regression models were used to evaluate the relationship between sdLDL-C/HDL-C and carotid intima-media thickness.Results With the increase of sdLDL-C/HDL-C quartile level,CIMT level also increased gradually.Binary logistic regression analysis showed that the Q1 of sdLDL-C/HDL-C was used as the reference,and the OR of abnormal CIMT in the Q4 after multivariate adjustment was 3.72(95%CI 1.86-7.41).Restricted cubic spline regression showed that sdLDL-C/HDL-C was linearly correlated with abnormal CIMT(P<0.001).In addition,in the subsample population with normal LDLC level(n=991),the correlation between sdLDL-C/HDL-C and CIMT was remaining significant.Conclusion The increase of sdLDL-C/HDL-C is positively correlated with CIMT in the physical examination population,and it is remaining positively correlated with the normal LDL-C level in the population.sdLDL-C/HDL-C is a promising predictor of carotid artery thickness.

关 键 词：颈动脉内膜中层厚度 动脉粥样硬化 小而密低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值 

分 类 号：R543[医药卫生—心血管疾病]