酰胺类化合物的水相合成研究进展  

Research Progress on Aqueous Synthesis of Amides

作　　者：韩龙飞 李龙龙 李国亭 刘辉 Han Longfei;Li Longlong;Li Guoting;Liu Hui(School of Environmental and Municipal Engineering,North China University of Water Resources and Electric Power,Zhengzhou 450046,China)

机构地区：[1]华北水利水电大学环境与市政工程学院,河南郑州450046

出　　处：《云南化工》2023年第5期5-9,共5页Yunnan Chemical Technology

基　　金：河南省重点研发与推广专项(232102311166,192102310029);华北水利水电大学校级大学生创新创业项目(2021XB124)。

摘　　要：酰胺类化合物在化学化工、生物医药等领域有着广泛的应用,酰胺键的合成是有机合成中最重要的反应之一。传统的合成方法使用无水条件,成本较高,并且存在溶剂浪费与环境污染等问题。近年来涌现出多种新型的酰胺键合成方法,其中符合绿色化学要求的水相合成酰胺得到了较多关注。该文总结了水相条件下羧酸和有机胺直接合成酰胺的最新研究,分别从微波辅助的水相合成、新型偶联试剂的水相合成、表面活性剂促进的水相合成以及其他类型等四个方面进行阐述。Amide compounds are widely used in chemical engineering,biomedicine and other fields.The synthesis of amide bonds is one of the most important reactions in organic synthesis.The traditional method requires anhydrous conditions,which causes high cost,solvent waste and environmental pollution and other problems.A variety of novel amide forming methodologies has emerged in recent years,among which the aqueous method has received more attention,for it is consistent with green chemistry requirement.This paper summarizes the latest research on the direct synthesis of amide bonds from carboxylic acid and amine in water.It is described from four aspects:microwave-assisted aqueous synthesis,aqueous synthesis using new coupling reagents,surfactant-promoted aqueous synthesis and other types.

关 键 词：酰胺键 水相合成 偶联试剂 表面活性剂 

分 类 号：O621[理学—有机化学]