慢性丙肝患者HCV-RNA载量与血清25-OH-D_(3)、铁代谢表达相关性的分析  

Correlation of HCV-RNA load with serum 25-OH-D_(3)and iron metabolism in patients with chronic hepatitis C

作　　者：李楠楠 LI Nannan(Department of Clinical Laboratory Medieine,Kaifeng Second Hospital of Traditional Chinese Medicine,Henan Kaifeng 475001)

机构地区：[1]开封市第二中医院检验科,河南开封475001

出　　处：《医学检验与临床》2023年第4期30-32,11,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探讨慢性丙型肝炎患者核糖核酸(HCV-RNA)载量与末梢血血清25羟维生素D3(25-OH-D_(3))、铁代谢表达的相关性,以期为临床提供有效的诊治依据。方法:选取2019年11月-2020年11月我院接受的83例慢性丙型肝炎患者作为研究对象,根据HCV-RNA水平将病例分为高载量组(n=48,1×10^(6)~1×10^(8)copy/mL)与低载量组(n=35,1×10^(3)~1×10^(6)copy/mL),采用酶联免疫吸附检测各组血清25-OH-D3,自动生化分析法检测铁代谢相关指标,对上述结果进行统计学分析。结果:高载量组中阳性45例,阳性率为93.75%,低载量组中阳性12例,阳性率为34.29%;高载量组25-OH-D_(3)水平明显低于低载量组(P<0.05);高载量组血清铁(SI)、血清铁蛋白(SF)明显高于低载量组,总铁结合力(TIBC)明显低于低载量组(P<0.05);经Pearson相关性分析显示慢性丙型肝炎患者HCV-RNA与25-OH-D3水平、TIBC呈显著的负相关(P<0.05),与SI、SF呈显著的正相关(P<0.05)。结论:慢性丙型肝炎患者HCV-RNA载量与血清25-OH-D_(3)、铁代谢指标均具有明显相关性,均可作为其长期治疗的重要观察指标,而且也提示25-OH-D_(3)可能是慢性丙型肝炎的保护因素,能通过补充25-OH-D_(3)改善患者临床症状。Objective:To investigate the correlation of hepatitis C virus ribonucleic acid(HCV-RNA)load with serum 25-hydroxyvitamin D_(3)(25-OH-D_(3))and iron metabolism in patients with chronic hepatitis C so as to provide an effective basis for clinical diagnosis and treatment.Methods:A total of 83 patients with chronic hepatitis C admitted to the hospital were selected as the research subjects between November 2019 and November 2020.According to the HCV-RNA level,the patients were divided into high load group(n=48,1×10^(6)~1×10^(8)copy/mL)and low load group(n=35,1×10^(3)~1×10^(6)copy/mL).The level of serum 25-OH-D_(3)was detected by enzyme-linked immunosorbent assay,and iron metabolism related indexes were detected by full-automatic biochemical analyzer for statistical analysis.Results:There were 45 positive cases in the high load group,with a positive rate of 93.75%,and 12 positive cases in the low load group,with a positive rate of 34.29%.The 25-OH-D_(3)level in the high load group was significantly lower than that in the low load group(P<0.05).Serum iron(SI)and serum ferritin(SF)in the high load group were significantly higher than those in the low load group,and the total iron binding capacity(TIBC)was significantly lower than that of the low load group(P<0.05).Pearson correlation analysis showed that HCV-RNA load was negatively correlated with 25-OH-D_(3)level and TIBC(P<0.05),while positively correlated with SI and SF(P<0.05).Conclusion:HCV-RNA load is significantly correlated with serum 25-OH-D_(3)and iron metabolism indexes in patients with chronic hepatitis C,which suggests that these indicators can be used for observing long-term treatment.They can be applied as the diagnostic indexes of chronic hepatitis C.25-OH-D_(3)may be a protective factor of chronic hepatitis C.The clinical symptoms of patients can be improved by supplementing 25-OH-D_(3).

关 键 词：慢性丙型肝炎 核糖核酸载量 末梢血血清 25羟维生素D_(3) 铁代谢指标 相关性 

分 类 号：R512.63[医药卫生—内科学]