中药复方汤剂多成分自组装纳米相态的形成原理及现状探析  

Analysis on the formation principle and present situation of nano phase state of multi⁃component self⁃assembly of traditional Chinese compound medicine decoction

作　　者：管庆霞[1] 周小影 吕邵娃[1] 杨芳芳 聂泽卉 林泽瑜 王艳宏[1] GUAN Qing-xia;ZHOU Xiao-ying;LÜShao-wa;YANG Fang-fang;NIE Ze-hui;LIN Ze-yu;WANG Yan-hong(College of pharmacy Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150000

出　　处：《海南医学院学报》2023年第11期872-880,共9页Journal of Hainan Medical University

基　　金：国家自然科学基金面上项目(816736112017);黑龙江省科学基金面上项目(H2016076);哈尔滨市科技创新人才研究专项资金(2017RAQXJ090)。

摘　　要：中药汤剂是含真溶液、胶体溶液、乳浊液和混悬液的一个复杂的多分散相体系。中药复方汤剂成分复杂,多含有皂苷、生物碱、多糖、黄酮、氨基酸等,在煎煮过程可自组装形成凝胶、纤维、胶束、囊泡等。自组装纳米相态不仅中和单味药性、减少毒副作用,而且各成分都有其各自的药理功效,相辅相成实现协同增效的效果,从而达到药辅合一作用,具有研究意义。本文讨论中药复方汤剂多成分自组装形成原理、增溶增效原理及表征方法。Traditional Chinese medicine decoction is a complex polydispersed phase system containing real solution,col⁃loid solution,emulsion and suspension.The compound decoction of traditional Chinese medicine has complex components,includ⁃ing saponins,alkaloids,polysaccharides,flavonoids,amino acids and so on,which can be self⁃assembled to form gels,fibers,mi⁃celles,vesicles and so on.The self⁃assembled nano⁃phase not only neutralizes the single drug and reduces the toxicity and side ef⁃fects,but also has its own pharmacological effects,which complement each other to achieve synergistic effect,so as to achieve the role of drug supplement,which is of research significance.The formation principle,solubilization and synergism principle and char⁃acterization method of multi⁃component self⁃assembly of traditional Chinese medicine compound decoction are discussed in this pa⁃per.

关 键 词：中药复方汤剂 多成分 自组装 形成原理 增溶 

分 类 号：R283.6[医药卫生—中药学]