ZA6-1锌合金骨植入体表面沉积抗菌及耐腐蚀型生物活性涂层  

Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant

作　　者：赵德人 陈栋 封雪 陈滋霖 金宸 谭小东 向芸颉 焦文博 方亚星 徐立群[1,2] 张永平 饶席 De-ren ZHAO;Dong CHEN;Xue FENG;Zi-lin CHEN;Chen JIN;Xiao-dong TAN;Yun-jie XIANG;Wen-bo JIAO;Ya-xing FANG;Li-qun XU;Yong-ping ZHANG;Xi RAO(School of Materials and Energy,Southwest University,Chongqing 400715,China;Chongqing Key Laboratory of Soft-matter Material Chemistry and Function Manufacturing,Southwest University,Chongqing 400715,China;School of Food Science,Southwest University,Chongqing 400715,China;Department of Clinical Laboratory,University-Town Hospital of Chongqing Medical University,Chongqing 401331,China)

机构地区：[1]西南大学材料与能源学院,重庆400715 [2]西南大学软物质材料化学与功能制造重庆市重点实验室,重庆400715 [3]西南大学食品科学学院,重庆400715 [4]重庆医科大学附属大学城医院检验科,重庆401331

出　　处：《Transactions of Nonferrous Metals Society of China》2023年第5期1507-1521,共15页中国有色金属学报（英文版）

基　　金：National Natural Science Foundation of China(No.51801164);the Fundamental Research Funds for the Central Universities,China(No.XDJK2020C005);Chongqing Key Laboratory Fund of Soft-matter Material Chemistry and Function Manufacturing,China(No.20200006);Chongqing College Student Innovation and Entrepreneurship Program of Southwest University,China(No.202010635076).

摘　　要：通过在商用ZA6-1锌合金表面沉积负载十二烷基硫酸钠(SDS)和乙酰丙酸(LA)的聚乳酸羟基乙酸共聚物(PLGA)赋予其抗菌性能。首先,在ZA6-1锌合金表面聚合化沉积APTES接枝层,获得氨基官能团;随后,利用氨基官能团与羧基官能团的正负电荷吸引作用使与SDS/LA混合的PLGA负载于基体表面。所制备的PLGA−SDS/LA涂层具有良好的耐腐蚀能力,其腐蚀速率低至0.005 mm/a,并且可通过改变涂层厚度对其进行调控。该涂层除具有良好的成骨细胞相容性外,还具有优良的抗菌性能,其对金黄色葡萄球菌和大肠杆菌的抗菌率分别达到98.9%和99.8%。The commercial zinc aluminum alloy(ZA6-1)surface was functionalized with poly-(lactic-co-glycolic)acid(PLGA)containing sodium dodecyl sulfate(SDS)and levulinic acid(LA)for gaining antibacterial activity.A polymerized 3-aminopropyltriethoxysilane(APTES)layer was initially fabricated on the surface of ZA6-1 alloy to gain amino group,and the PLGA mixed with SDS/LA was subsequently immobilized on the as-treated surface through the electrostatic interaction between amino group and carboxyl group.The PLGA−SDS/LA coating on zinc alloy showed extremely good corrosion resistance with the degradation rate of 0.005 mm/a,which can be adjusted by varying the coating thickness.Furthermore,besides the good biocompatibility to osteoblasts,the PLGA−SDS/LA coating exhibited excellent antibacterial property,and the bactericidal rates against Staphylococcus aureus and Escherichia coli were 98.9%and 99.8%,respectively.

关 键 词：锌合金 聚合物涂层 抗菌性能 生物相容性 腐蚀行为 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]